Clopidogrel reduces the inflammatory response of lung in a rat model of decompression sickness

Respiratory Physiology & Neurobiology
Xiao-Chen BaoFang-Fang Wang

Abstract

Inflammation and platelet activation are critical phenomena in the setting of decompression sickness. Clopidogrel (Clo) inhibits platelet activation and may also reduce inflammation. The goal of this study was to investigate if Clo had a protective role in decompression sickness (DCS) through anti-inflammation way. Male Sprague-Dawley rats (n=111) were assigned to three groups: control+vehicle group, DCS+vehicle, DCS+Clo group. The experimental group received 50 mg/kg of Clo or vehicle for 3 days, then compressed to 1,600 kPa (150 msw) in 28 s, maintained at 150 msw for 242 s and decompressed to surface at 3m/s. In a control experiment, rats were also treated with vehicle for 3 days and maintained at atmospheric pressure for an equivalent period of time. Clinical assessment took place over a period of 30 min after surfacing. At the end, blood samples were collected for blood cells counts and cytokine detection. The pathology and the wet/dry ratio of lung tissues, immunohistochemical detection of lung tissue CD41 expression, the numbers of P-selectin positive platelets and platelet-leukocyte conjugates in blood were tested. We found that Clo significantly reduced the DCS mortality risk (mortality rate: 11/45 with Clo vs. 28/46 i...Continue Reading

References

Dec 13, 2000·Neurology·P CordesG Deuschl
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Jul 26, 2005·British Journal of Pharmacology·Laura MoleroCarlos Macaya
Oct 26, 2005·Journal of Thrombosis and Haemostasis : JTH·E FalcinelliP Gresele
Mar 1, 2006·Critical Care Medicine·Hsing I ChenShang-Jyh Kao
Dec 5, 2006·The Journal of Clinical Investigation·Alexander ZarbockKlaus Ley
Dec 26, 2006·Expert Review of Cardiovascular Therapy·Marco Cattaneo
Feb 3, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ali Emad, Yasaman Emad
Jan 30, 2008·Aviation, Space, and Environmental Medicine·Elizabeth A Montcalm-SmithSusan R Kayar
Aug 23, 2008·Aviation, Space, and Environmental Medicine·Jean-Michel PontierNicolas Vallée
Dec 17, 2008·Aviation, Space, and Environmental Medicine·Emmanuel GemppChristophe Pény
Dec 17, 2008·Seminars in Thrombosis and Hemostasis·Anoop K EnjetiMichael Seldon
Dec 24, 2008·Postgraduate Medical Journal·D Z H Levett, I L Millar
Jun 15, 2010·Aviation, Space, and Environmental Medicine·Romuald OlszańskiJoachim F Schenk
Oct 23, 2010·Journal of Applied Physiology·Stephen R ThomTatyana N Milovanova
Jan 8, 2011·Journal of Applied Physiology·Jean-Michel PontierLionel Bourdon
Jul 16, 2011·Journal of Applied Physiology·Ye ChenRichard M McCarron
Jun 28, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jean-Michel PontierMihaela Ignatescu
Aug 2, 2013·Scandinavian Journal of Medicine & Science in Sports·W HemelryckC Balestra

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Citations

Jul 22, 2017·Medicine and Science in Sports and Exercise·Jacky LautridouFrançois Guerrero
Mar 17, 2018·Frontiers in Physiology·Aleksandra MazurFrançois Guerrero
Jun 26, 2021·Frontiers in Veterinary Science·Alicia Velázquez-WallrafYara Bernaldo de Quirós
Aug 27, 2021·European Journal of Applied Physiology·Emmanuel DugrenotFrançois Guerrero

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