Clopidogrel-taking behavior by drug-eluting stent patients: Discontinuers versus continuers.

Patient Preference and Adherence
Carole DeckerJohn A Spertus

Abstract

Each day, patients make choices whether or not to take their prescribed medications. Previous research has shown that 1 in 7 myocardial infarction (MI) patients discontinued thienopyridines within 1 month of receiving a drug-eluting stent (DES) with serious consequences. This qualitative research study explored in depth the clopidogrel-taking behavior among DES-treated patients who quit taking clopidogrel 1 month after treatment and those who continued therapy. Sequential patients from a prospective MI registry who reported discontinuing clopidogrel within 30 days of DES treatment (N = 11) were matched with continuers (N = 11). Both groups underwent detailed qualitative phone interviews. Coding and thematic representation using directed qualitative content analysis by 3 PhD researchers was done. Patients were 41-77 years old and the majority was Caucasian and male. Multiple barriers were described by discontinuers that were not reported by continuers. The most frequently cited barrier was misunderstanding the intended duration of treatment. Discontinuers also described system weaknesses that contributed to early discontinuance such as gaps in the transition to primary care. While premature discontinuation of a prescribed therap...Continue Reading

References

Oct 1, 1992·Journal of Clinical Pharmacy and Therapeutics·L S Morris, R M Schulz
Jan 1, 1985·Social Science & Medicine·P Conrad
Feb 1, 1974·Social Science & Medicine·G V Stimson
Jan 1, 1984·Health Education Quarterly·N K Janz, M H Becker
Jan 1, 1995·International Clinical Psychopharmacology·P E Bebbington
Dec 1, 1996·Family Practice·M N Marshall
Oct 27, 2001·Journal of Clinical Pharmacy and Therapeutics·E VermeireJ Denekens
Sep 10, 2002·Medical Care·M Robin DiMatteoThomas W Croghan
Aug 17, 2004·American Heart Journal·Deepak L BhattUNKNOWN Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance Executive Committee
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Oct 6, 2005·The Annals of Pharmacotherapy·Anchal SudSteven R Erickson
Oct 6, 2005·Qualitative Health Research·Hsiu-Fang Hsieh, Sarah E Shannon
Nov 24, 2005·Chest·Johnson GeorgeKay Stewart
Sep 27, 2006·Archives of Internal Medicine·P Michael HoJohn S Rumsfeld
Sep 27, 2006·Archives of Internal Medicine·Derjung M TarnNeil S Wenger
Nov 14, 2006·American Journal of Health Behavior·Cynthia L RussellPeeranuch Jantarakupt
Dec 7, 2006·JAMA : the Journal of the American Medical Association·Eric L EisensteinRobert M Califf

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Citations

May 7, 2014·Clinical Cardiology·Matthew J CzarnyLaura Mauri
Apr 2, 2013·Journal of the American College of Cardiology·Amit P AminRichard G Bach
May 14, 2014·Annals of Family Medicine·Mohammed A RashidJonathan Mant
May 21, 2010·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Linda GaravaliaCarole Decker

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