Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease

Diabetes
Dominick J AngiolilloCarlos Macaya

Abstract

Inhibition of the P2Y12 pathway by the platelet antagonist clopidogrel is associated with a marked reduction in platelet reactivity. Recent reports have shown that P2Y12 inhibition has anti-inflammatory effects as well. However, whether clopidogrel withdrawal is associated with proaggregatory and proinflammatory effects has not yet been explored. Since diabetic subjects are characterized by a prothrombotic and proinflammatory status, we hypothesize that these patients may be more vulnerable to these effects. A total 54 patients with diabetes on long-term (12 months) dual antiplatelet therapy (aspirin plus clopidogrel) were studied. Platelet aggregation (following 6 and 20 micromol/l ADP stimuli) and inflammatory markers (C-reactive protein and P-selectin expression) were assessed before and 1 month following clopidogrel withdrawal. Following clopidogrel withdrawal, aspirin responsiveness using platelet function analyzer-100 was determined as well. A significant increase in all the assessed platelet (P < 0.0001 for 6 and 20 micromol/l ADP-induced aggregation) and inflammatory (P < 0.05 for C-reactive protein, P < 0.001 for P-selectin expression in resting platelets, and P < 0.0001 for P-selectin expression in ADP-stimulated plat...Continue Reading

References

May 31, 1990·The New England Journal of Medicine·M D TripJ Vreeken
Dec 10, 1999·Journal of Thrombosis and Thrombolysis·D FengG H Tofler
Mar 7, 2001·International Journal of Cardiology·J P ColletP G Steg
Jul 27, 2001·The American Journal of Cardiology·P A GumE J Topol
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Aug 13, 2002·Current Opinion in Hematology·Emmanuel J Favaloro
Sep 17, 2002·The American Journal of Cardiology·Deepak L BhattEric J Topol
Nov 19, 2002·JAMA : the Journal of the American Medical Association·Steven R SteinhublUNKNOWN CREDO Investigators. Clopidogrel for the Reduction of Events During Observation
Apr 8, 2003·Journal of the American College of Cardiology·Giuseppe G L Biondi-ZoccaiLuigi M Biasucci
Jul 2, 2003·Diabetes Care·John A Colwell, Richard W Nesto
Apr 23, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Pilar Jiménez-QuevedoManel Sabaté
Jul 28, 2004·The American Journal of Cardiology·Deepak P VivekananthanEric J Topol
Aug 17, 2004·American Heart Journal·Deepak L BhattUNKNOWN Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance Executive Committee
Nov 30, 2004·Thrombosis Research·Waiel M SamaraPaul A Gurbel
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Jun 7, 2005·Journal of the American College of Cardiology·Peter WenaweserOtto M Hess
Jun 7, 2005·Journal of the American College of Cardiology·Nadine AjzenbergPh Gabriel Steg
Jun 10, 2005·Acta Diabetologica·S Fateh-MoghadamW Bocksch
Jul 26, 2005·British Journal of Pharmacology·Laura MoleroCarlos Macaya
Sep 20, 2005·Journal of the American College of Cardiology·Peter J MasonJane E Freedman
Nov 16, 2005·Journal of the American College of Cardiology·Paul A GurbelUdaya S Tantry
Nov 16, 2005·Journal of the American College of Cardiology·Paul A GurbelUdaya S Tantry

❮ Previous
Next ❯

Citations

Jun 2, 2007·Der Anaesthesist·W Lepper, M Kelm
Apr 4, 2007·Journal of Thrombosis and Thrombolysis·Lukasz A MalekGrzegorz Opolski
Apr 10, 2008·Journal of Thrombosis and Thrombolysis·Srinivas Iyengar, LeRoy E Rabbani
May 27, 2011·Journal of Thrombosis and Thrombolysis·David VivasAntonio Fernández-Ortiz
Nov 15, 2011·Journal of Thrombosis and Thrombolysis·Idit YedidyaEli I Lev
Feb 15, 2012·Journal of General Internal Medicine·Eira RothMichael Elnicki
Mar 12, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Olivier MorelThierry Hannedouche
Feb 24, 2010·AIDS·Claudette S SatchellPatrick W G Mallon
Jul 14, 2007·Annals of the Rheumatic Diseases·Andrea Lo MonacoFrancesco Di Virgilio
Jun 15, 2011·Thrombosis and Haemostasis·Joseph A JakubowskiKenneth J Winters
Jul 18, 2008·Anesthesia and Analgesia·Lisa T NewsomeRoger L Royster
Jan 31, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Craig S McLachlanShu-Hui Chia
Nov 30, 2007·Journal of the American Society of Nephrology : JASN·Xiaowen TuJianjun Li
Nov 26, 2013·Journal of Cardiovascular Translational Research·Davide Capodanno, Corrado Tamburino
Jan 19, 2013·Ophthalmic Plastic and Reconstructive Surgery·Tiffany L Kent, Philip L Custer
May 7, 2010·Current Cardiology Reports·Amit P Amin, Steven P Marso
Nov 28, 2009·Basic Research in Cardiology·Philipp DiehlMartin Moser
Mar 13, 2010·Expert Review of Cardiovascular Therapy·Scot Garg, Patrick Serruys
Oct 1, 2011·International Journal of Cardiology·Bernardo Cortese, Alessandra Bertoletti
Feb 4, 2009·International Journal of Cardiology·Jean-Philippe Collet, Gilles Montalescot
Jan 23, 2009·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Victoria P TanAndrew E Ajani
Jun 24, 2008·Thrombosis Research·Yao-Zu XiangBo-Li Zhang
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Jan van der Linden
Apr 26, 2014·Thrombosis and Haemostasis·P AdamskiJ Kubica
Jan 13, 2015·Hämostaseologie·M Cattaneo
Jun 13, 2015·Thrombosis and Haemostasis·Sanne Bøjet LarsenSteen Dalby Kristensen
Aug 1, 2015·Thrombosis and Haemostasis·Karin A L MüllerTobias Geisler
Dec 18, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Dominick J AngiolilloTheodore A Bass

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

© 2021 Meta ULC. All rights reserved