Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions

Journal of the European Academy of Dermatology and Venereology : JEADV
A NishizawaH Yokozeki

Abstract

Lichen planus (LP) is a common skin disorder of unknown aetiology that affects the skin, mucous membranes and nails. Although metal allergies have been implicated in the development of oral LP (OLP), the contribution of these allergies to nail LP (NLP) has yet to be studied in detail. To elucidate the link between metal allergy and NLP. We retrospectively analysed 115 LP patients with respect to the contribution of metals to either NLP or OLP. We also attempted to detect the specific metals involved in these nail lesions. Of the 79 patients that received a metal patch test (PT), 24 (30%) were positive for at least one of the metal compounds tested. Notably, the prevalence of positive reactions to metals in the NLP patients was significantly higher as compared with the OLP patients (59% vs. 27%, P < 0.05). Among the 10 PT-positive patients with NLP, improvement of the skin lesions was seen in six of the patients after removal of dental materials containing causative metals or systemic disodium cromoglycate therapy. On the other hand, only 3 of 16 PT-positive patients with OLP exhibited improvement after the removal of dental materials. Causative metals in the dental fillings/braces were detected in the involved nail tissues. Thi...Continue Reading

References

May 1, 1993·Journal of the American Academy of Dermatology·A TostiB M Piraccini
Aug 30, 2001·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·L A ScalfS W Looney
Jun 28, 2003·The British Journal of Dermatology·Y KatoK Ozeki
Jul 1, 1961·The British Journal of Dermatology·P D SAMMAN
May 13, 2005·The British Journal of Dermatology·H YokozekiK Nishioka

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Citations

Mar 1, 2016·Current Allergy and Asthma Reports·John J KohorstRochelle R Torgerson
Mar 23, 2021·Dermatologic Clinics·Mohit Kumar Gupta, Shari R Lipner
Jun 8, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Farzan SolimaniKatharina Meier

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