PMID: 16623404Apr 21, 2006Paper

Closed-circuit anesthesia preserves skin blood flow during surgery

Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists
Ya-Ching KeChih-Cherng Lu

Abstract

Closed-circuit anesthesia (CCA) has been suggested to provide better hemodynamic stability, but the relative contribution of CCA to the control of blood flow in microcirculation is not defined. It is hypothesized that isoflurane-based CCA provides a favorable skin blood flow mediating via lesser circulatory response to surgical stimulation. This study was purposed to compare the effects of isoflurane conveyed by CCA with that by semiclosed anesthesia (SCA) on the preservation of skin blood flow in the forearm. Twenty seven patients scheduled for colorectal surgery were enrolled for the study and randomly assigned to one of two groups, either receiving CCA (n=14) or SCA (n=13). Anesthesia was induced with fentanyl (100 ig) and thiopental (4-5 mg/kg), and intubation was facilitated with pancuronium priming (0.015 mg/kg) and succinylcholine (1.25 mg/kg). Two percent isoflurane in high O2 flow (3 L/min) was given for 10 min to each patient initially to wash isoflurane in the functional residual capacity of both lungs and the breathing circuit. In the CCA group, after insoflurane wash-in the 02 flow was reduced less than 250 mL/min with isoflurane vaporizer setting adjusted to 3-5% to keep inspired isoflurane at 2% for maintenance o...Continue Reading

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