Closed loop control of rate adaptive pacing: clinical assessment of a system analyzing the ventricular depolarization gradient.

Pacing and Clinical Electrophysiology : PACE
V PaulA J Camm

Abstract

Closed loop control of rate adaptive pacing has theoretical advantages over current rate responsive pacemakers. The first available system (which senses the ventricular depolarization gradient) has been evaluated in ten patients. The pacing response to a variety of exercise and nonexercise stimuli was assessed. Response to isotonic exercise was prompt and proportional to the exertion involved while isometric exercise and mental stress produced obvious but more gradual increases in pacing rate. In seven patients, comparison between the intrinsic P wave and pacing rate showed a high correlation during exercise (r = 0.91) and mental activity (r = 0.87). Postural changes induced a paradoxical response. Closed loop rate responsive pacing based upon analysis of the ventricular depolarization gradient produces a fast and appropriate rate response to most physiological stimuli.

References

Feb 1, 1988·Pacing and Clinical Electrophysiology : PACE·A P EconomidesS Gergely
Oct 1, 1988·Pacing and Clinical Electrophysiology : PACE·D MehtaA J Camm
Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·A R LivingstonJ J Chappin
Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·C L ByrdJ J Greenberg
Feb 1, 1989·Pacing and Clinical Electrophysiology : PACE·C P LauA J Camm
Jun 1, 1989·Journal of the American College of Cardiology·C R Conti

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Citations

Mar 10, 2000·Cardiology Clinics·S K Leung, C P Lau
May 1, 1991·Pacing and Clinical Electrophysiology : PACE·K LasaridisA J Camm
Aug 1, 1992·Pacing and Clinical Electrophysiology : PACE·C P Lau
Jan 3, 2019·International Neurourology Journal·Eunkyoung ParkKyu-Sung Lee
Jun 2, 2000·Pacing and Clinical Electrophysiology : PACE·M H Schoenfeld, H T Markowitz

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