Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans.

British Journal of Anaesthesia
H SchwildenJ Schüttler


Propofol was administered for 2 h to 11 volunteers by an adaptive feedback control algorithm based on quantitative EEG analysis. Median EEG frequency served as the control variable. The range 2-3 Hz was chosen as the target range of control. During the feedback period, volunteers did not respond to commands and eyelash reflex was abolished. An average median frequency of 2.5 (SD 0.3) Hz was obtained by administering propofol 1452 (262) mg within 2 h. Time to recovery was 17.9 (8.0) min. Compared with a study with methohexitone using the same approach, the relative potency of propofol was 0.72. The mean recovery time was less than half that observed after methohexitone.


Aug 1, 1994·International Journal of Clinical Monitoring and Computing·G M Gurman
Aug 11, 1992·Electroencephalography and Clinical Neurophysiology·R V ReddyR D Deitch
Jan 1, 1991·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·T M ItilE Eralp
Apr 1, 1992·Computer Methods and Programs in Biomedicine·S G GreenhowA J Asbury
May 1, 1995·Biological Psychology·A T PopeD S Bartolome
Feb 5, 1996·Biological Psychology·E A Byrne, R Parasuraman
Jul 29, 1998·Electroencephalography and Clinical Neurophysiology·J M Guérit
Sep 1, 1997·Artificial Intelligence in Medicine·S E KernD R Westenskow
Jan 16, 2007·British Journal of Anaesthesia·H IhmsenE Kochs
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Nov 10, 2013·PLoS Computational Biology·Maryam M ShanechiEmery N Brown
Jun 24, 2004·Biomedizinische Technik. Biomedical Engineering·C JeleazcovH Schwilden
Jan 1, 1994·British Journal of Neurosurgery·B J AndersonM E Futter
Sep 19, 2009·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Govardhan Dutt Puri, Preethy Joseph Mathew
May 20, 2009·Best Practice & Research. Clinical Anaesthesiology·Wassim M Haddad, James M Bailey
May 9, 2008·Clinical Pharmacology and Therapeutics·P J ManbergS D Kelley
Feb 24, 2001·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·A GentiliniA M Zbinden
Jan 27, 1999·IEEE Transactions on Bio-medical Engineering·J W HuangR J Roy
Aug 14, 2001·IEEE Transactions on Bio-medical Engineering·A GentiliniT W Schnider
Mar 25, 2005·IEEE Transactions on Neural Networks·Tomohisa HayakawaNaira Hovakimyan
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·Michel M R F StruysTom De Smet
Jan 1, 1994·Annales Françaises D'anesthèsie Et De Rèanimation·X Viviand
Jan 5, 2002·The International Journal of Aviation Psychology·L J PrinzelA T Pope
Dec 2, 2000·International Anesthesiology Clinics·T Dorman, J Fackler
Aug 28, 2007·Anesthesiology·Michel M R F StruysSteven L Shafer

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.