Closed-Loop Temperature Control Based on Fiber Bragg Grating Sensors for Laser Ablation of Hepatic Tissue

Sensors
Sanzhar KorganbayevP Saccomandi

Abstract

Laser ablation (LA) of cancer is a minimally invasive technique based on targeted heat release. Controlling tissue temperature during LA is crucial to achieve the desired therapeutic effect in the organs while preserving the healthy tissue around. Here, we report the design and implementation of a real-time monitoring system performing closed-loop temperature control, based on fiber Bragg grating (FBG) spatial measurements. Highly dense FBG arrays (1.19 mm length, 0.01 mm edge-to-edge distance) were inscribed in polyimide-coated fibers using the femtosecond point-by-point writing technology to obtain the spatial resolution needed for accurate reconstruction of high-gradient temperature profiles during LA. The zone control strategy was implemented such that the temperature in the laser-irradiated area was maintained at specific set values (43 and 55 °C), in correspondence to specific radii (2 and 6 mm) of the targeted zone. The developed control system was assessed in terms of measured temperature maps during an ex vivo liver LA. Results suggest that the temperature-feedback system provides several advantages, including controlling the margins of the ablated zone and keeping the maximum temperature below the critical values. Our...Continue Reading

References

Mar 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D N WheatleyD W Gregory
Jan 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P H MöllerK G Tranberg
Jul 21, 2006·European Journal of Radiology·Hans-Joachim SchwarzmaierFrank Ulrich
Mar 21, 2009·Current Problems in Diagnostic Radiology·Christopher L Brace
Jun 15, 2010·Gastrointestinal Endoscopy·Francesco Di MatteoGuido Costamagna
Aug 7, 2010·Journal of Vascular and Interventional Radiology : JVIR·Meghan G LubnerFred T Lee
Dec 24, 2010·Critical Reviews in Biomedical Engineering·R Jason StaffordKamran Ahrar
Jan 29, 2011·Radiology·Muneeb AhmedS Nahum Goldberg
May 20, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Pavel S YarmolenkoMark W Dewhirst
May 24, 2011·World Journal of Clinical Oncology·Yu-Feng Zhou
Jan 19, 2012·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·P SaccomandiS Silvestri
Oct 1, 2005·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·L SunN B Smith
Aug 30, 2012·IEEE Transactions on Bio-medical Engineering·Paola SaccomandiSergio Silvestri
Sep 17, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Paola SaccomandiSergio Silvestri
Feb 25, 2014·Nature Reviews. Cancer·Katrina F Chu, Damian E Dupuy
Sep 1, 2011·IEEE Pulse·C Brace
Jun 15, 2017·Journal of Functional Biomaterials·Emiliano SchenaYuman Fong
Jan 13, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Paola SaccomandiFrancesco M Di Matteo
Feb 17, 2018·Gastrointestinal Endoscopy·Francesco Maria Di MatteoGuido Costamagna
Nov 16, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Paola SaccomandiGiuseppe Quero
Jan 11, 2020·Lasers in Surgery and Medicine·Vivek Krishna NagarajanBing Yu
Aug 4, 2020·IEEE Transactions on Bio-medical Engineering·Elena De VitaStefania Campopiano

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