PMID: 16634427Apr 26, 2006Paper

Closed loops in anaesthesia

Best Practice & Research. Clinical Anaesthesiology
M M R F StruysTom De Smet

Abstract

Closed-loop systems are able to make their own decisions and to try to reach and maintain a preset target. As a result, they might help the anaesthetist to optimise the titration of drug administration without any overshoot, controlling physiological functions and guiding monitoring variables. Thanks to the development of fast computer technology and more reliable pharmacological effect measures, the study of automation in anaesthesia has regained popularity. This short review focuses on the most recently developed and tested feedback systems in anaesthesia. Various new approaches for controlling the administration of intravenous and inhaled hypnotic-anaesthetic drugs have recently been published. For analgesics, a framework for further research has been presented in the literature. For other drugs, such as muscle relaxants and haemodynamic agents, only short reviews can be found. Until now, most of these systems have had to be under development. The challenge is now fully to establish the safety, efficacy, reliability and utility of closed-loop anaesthesia so that it can be adopted in the clinical setting. Besides, their role in optimising the controlled variables and control models, these systems have to be tested in extreme ...Continue Reading

References

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Citations

Jun 10, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas M HemmerlingPierre A Mathieu
Mar 30, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Siv Cathrine Høymork
Dec 7, 2010·Journal of Clinical Monitoring and Computing·Stéphane BibianTatjana Zikov
Jan 15, 2014·Clinical EEG and Neuroscience·Nicolas MarchantVincent Bonhomme
Apr 7, 2007·Anesthesiology·Evan D Kharasch
Apr 11, 2008·The Journal of Trauma·Ronald PauldineDavid W Kaczka
Apr 24, 2008·Clinical Pharmacology and Therapeutics·M M R F StruysE P Mortier
Jun 20, 2008·Clinical Pharmacology and Therapeutics·D K Gupta, E I Eger
Nov 6, 2018·Minerva anestesiologica·José A RebosoJuan A Mendez-Perez
Dec 16, 2010·Anesthesia and Analgesia·Brett L MooreLarry D Pyeatt
Aug 5, 2009·Current Opinion in Anaesthesiology·Ben Julian A PalancaMichael S Avidan

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