Closed versus open vitrification for human blastocyst cryopreservation: A meta-analysis

Cryobiology
Hyun Sik YoumYong Ho Rho

Abstract

Closed vitrification can minimize the risk of microbiological transmission through liquid nitrogen during the cooling, storage, and warming procedures. As cooling rates may reduce when closed vitrification is applied, clinical outcomes should be compared between closed and open vitrification in order to justify the use of closed vitrification. This study was conducted to investigate the differences in survival, implantation, clinical pregnancy, and live birth rates between closed and open vitrification for human blastocyst cryopreservation. This systematic review and meta-analysis included 7 studies that reported survival, implantation, clinical pregnancy, or live birth rates following closed or open vitrification. There were no statistically significant differences in survival rates (risk ratio [RR]: 1.00, 95% confidence interval [CI]: 0.98-1.02), implantation rates (RR: 1.02, 95% CI: 0.93-1.11), clinical pregnancy rates (RR: 0.99, 95% CI: 0.89-1.10), and live birth rates (RR: 0.77, 95% CI: 0.58-1.03) between closed and open vitrification. Although there was no statistical significance, the tendency of lower live birth rates with closed vitrification than with open vitrification could be clearly identified. Therefore, it is no...Continue Reading

Citations

Jan 8, 2019·Human Fertility : Journal of the British Fertility Society·Julija GorodeckajaMichael Summers
May 8, 2019·Zygote : the Biology of Gametes and Early Embryos·Katerina ChatzimeletiouBasil C Tarlatzis
Sep 12, 2020·Human Fertility : Journal of the British Fertility Society·Detlef PietrowskiChristian Schneeberger
Mar 14, 2020·Theriogenology·Gábor Vajta
Dec 29, 2020·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine and Society of Reproductive Biologists and Technologis

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