Closing the pylorus decreases the size of large meals in the rat

Physiology & Behavior
J D DavisJ L Sayler

Abstract

We previously reported (Davis, J. D.; Smith G. P.; Sayler, J. L. Reduction of intake in the rat due to gastric filling. Am. J. Physiol. 272:R1599-R1605, 1997.) that confining ingested fluid to the stomach by closing the pylorus decreased the intake of solutions that stimulated particularly large intakes. Those solutions differed in the type of orosensory and postoral stimulation so the nature of the control over ingestion was unclear. We report here a study of the role of orosensory stimulation alone in controlling intake in rats with a closed pylorus. Rats were given 30-min intake tests with the pylorus open and closed with 0.2 M glucose, and with 0.2 M glucose + 1.25 mM sodium saccharin, 2.5 mM sodium saccharin and 5.0 mM sodium saccharin. Intake was reduced on the cuff-closed test relative to the cuff-open test with the two highest concentrations of saccharin, but not with the two lowest. When ingesting the glucose solutions with the two highest concentrations of saccharin the initial rate of ingestion was greater and the decline in the rate of ingestion was slower than when the rats ingested the glucose solutions with 1.25 mM saccharin or no saccharin. We showed by means of a meta-analysis of previously published and unpubl...Continue Reading

References

Nov 1, 1974·Journal of Comparative and Physiological Psychology·R C YoungG P Smith
Jun 1, 1973·Journal of Comparative and Physiological Psychology·J D Davis, C S Campbell
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Citations

Jan 11, 2007·Genes, Brain, and Behavior·J D BoughterD Heck
May 6, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshihiro KatsuuraSharif A Taha
Nov 9, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John-Paul BairdCarrie E Mahoney
May 26, 2004·Physiology & Behavior·Robert C Ritter
Aug 9, 2006·Behavioral Neuroscience·John-Paul BairdShannon G Fischer
Jul 6, 2004·Physiology & Behavior·John D Davis
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R HayesMihai Covasa
Jun 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John-Paul BairdAshley Layne Pecora
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S EisenG P Smith

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