Clostridial typhlitis associated with topical antibiotic therapy in a Syrian hamster

Laboratory Animals
L AlworthR Fish

Abstract

A Syrian hamster that had been treated with topical antibiotic ointment for 10 days following injuries sustained during fighting was presented moribund. Postmortem and microscopic examinations revealed lesions consistent with clostridial typhlitis and enteritis. Anaerobic culture of caecal contents resulted in the isolation of two Clostridium species, and caecal contents contained Clostridium difficile enterotoxins. Based on these findings, a diagnosis of acute C. difficile enterotoxaemia was made. This report discusses the pathogenesis of C. difficile enterotoxaemia and the potential role of topical antibiotic ointment therapy in initiating the disease.

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Citations

May 5, 2012·Gut Microbes·Emma L BestMark H Wilcox

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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