Clostridium difficile and Laparoscopic Bariatric Surgery: an Analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Database

Obesity Surgery
ThucNhi T DangShahzeer Karmali

Abstract

Obesity is associated with disturbances in the gut microbiota which is a risk factor for Clostridium difficile infection (CDI). Bariatric surgery can induce substantive changes to the gut microbiota which may affect the risk of developing CDI. The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program captures variables specific to bariatric surgery from 832 centers. Patients undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) in 2016 and 2017 were identified. Primary outcomes included the prevalence and predictors of CDI after bariatric surgery. A multivariable logistic regression model determined preoperative factors predictive of 30-day CDI. A total of 78,222 LRYGB and 222,968 LSG were included. The overall incidence of CDI was low with 0.13% developing CDI. Rates of CDI were two times higher after LRYGB compared to LSG (0.2 vs 0.1%, p < 0.001). Although CDI rates were low, CDI was associated with increased post-operative complications. Multivariable analysis identified chronic kidney disease (OR 2.37, 95%CI 1.09-5.15, p = 0.03) and history of venous thromboembolism (OR 2.06, 95%CI 1.29-3.29, p = 0.002) as being most predictive of developing CDI with more t...Continue Reading

References

Aug 21, 2004·Annals of Surgery·Nicolas V ChristouLloyd D MacLean
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Héctor F Escobar-MorrealeJosé L San Millán
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Sandra DialSamy Suissa
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Mar 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joseph F RodemannChristian D Stone
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C OwensCarlene A Muto
Jun 29, 2010·International Journal of Surgery·M A RodriguesA P Gibb
Nov 4, 2011·The New England Journal of Medicine·Vivian G LooAndre Dascal
Dec 7, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alan J ForsterCarl van Walraven
Apr 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aron J HallBen A Lopman
Nov 7, 2012·Mayo Clinic Proceedings·Mira T KeddisQi Qian
May 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jihad BisharaWilliam Nseir
Nov 6, 2013·Emerging Infectious Diseases·Jason LeungNahid Bhadelia
Nov 6, 2013·JAMA : the Journal of the American Medical Association·Anita P CourcoulasUNKNOWN Longitudinal Assessment of Bariatric Surgery (LABS) Consortium
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Sep 2, 2014·American Journal of Surgery·Galinos BarmparasEric J Ley
Feb 26, 2015·The New England Journal of Medicine·Fernanda C LessaL Clifford McDonald
Oct 30, 2016·Alimentary Pharmacology & Therapeutics·R MulkiP O Katz
Apr 14, 2017·Obesity Surgery·L AngrisaniN Scopinaro
May 30, 2017·Canadian Journal of Diabetes·Fernando F AnhêAndré Marette
Feb 7, 2018·Obesity Surgery·Hisham HussanSteven K Clinton
Mar 10, 2018·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Sandhya B KumarMatthew Y Lin

❮ Previous
Next ❯

Citations

May 21, 2021·Journal of the American College of Surgeons·Elisa Morales-MarroquinSarah E Messiah
Aug 15, 2021·American Journal of Surgery·Gregory StoneKamran Samakar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.