Abstract
To determine the prevalence, severity, and outcome associated with Clostridium difficile-associated disease (CDAD) acquired while in the cardiothoracic intensive care unit (CTICU). A 5-year retrospective study. The CTICU. All CTICU patients with a positive C difficile stool toxin assay 48 hours after admission. None. The results of all CTICU patients with a positive C difficile stool toxin assay were obtained from the Microbiology Department. Each patient's medical notes and charts then were reviewed in turn. A total of 27 of 5,199 (0.5%) CTICU patients acquired CDAD. The median age was 74 years (IQR 68-77), and 17 (63%) patients were male. There were 21 (78%) surgical patients; 13 (62%) were elective admissions. The most frequent diagnosis on admission was valvular heart disease (10 [37%] patients). Sixteen (59%) patients underwent coronary artery bypass graft (CABG) surgery and/or valvular heart surgery. The median interval between CTICU admission and CDAD diagnosis was 10 days (IQR 5-18). Previously identified risk factors for ICU-acquired CDAD included age >65 years (23), antibiotic use (26), and medical device requirements (27). At the time of diagnosis, 14 (52%) patients had moderate CDAD. After treatment initiation, 8 (3...Continue Reading
References
Feb 1, 1991·American Journal of Infection Control·T G EmoriR P Gaynes
Mar 20, 1999·Chest·D J WeberW A Rutala
Apr 30, 2004·The Journal of Infectious Diseases·Lennox K ArchibaldWilliam R Jarvis
Dec 14, 2005·The Journal of Infection·Ritesh AgarwalSurinder K Jindal
Feb 1, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Steven J LawrenceLinda M Mundy
Mar 27, 2007·The Annals of Thoracic Surgery·Traves CrabtreeRalph J Damiano
May 23, 2007·BMC Infectious Diseases·Alexandre R MarraGonzalo M L Bearman
Jun 19, 2007·Chest·Claire KenneallyMarin H Kollef
Sep 12, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patricia MuñozEmilio Bouza
Oct 11, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mathieu BeaulieuJean Lachaine
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N GerdingRobert C Owens
Feb 12, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Luca Salvatore De SantoMaurizio Cotrufo
Mar 26, 2008·Critical Care Clinics·Daniel M Musher, Saima Aslam
Apr 2, 2008·Critical Care Medicine·Naomi P O'GradyUNKNOWN Infectious Diseases Society of America
Nov 4, 2008·The Lancet Infectious Diseases·Tim PlancheSanjeev Krishna
Nov 18, 2008·The Journal of Infection·Chin Wee AngBryan Carr
Feb 17, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Teresa Inkster
Aug 4, 2009·BMC Medicine·Mary A M RogersBrahmajee K Nallamothu
Citations
Dec 7, 2013·World Journal of Gastroenterology : WJG·Nagham KhanaferPhilippe Vanhems
Dec 25, 2015·Anaerobe·Emilio BouzaElena Reigadas
Jun 19, 2013·Medicina intensiva·S SalvaUNKNOWN CRIPS Investigators
Jan 21, 2016·Open Forum Infectious Diseases·Styliani KaranikaEleftherios Mylonakis
Apr 2, 2013·The Journal of Thoracic and Cardiovascular Surgery·Brian T BatemanNiteesh K Choudhry
Apr 11, 2015·Epidemiology and Infection·J CzepielA Garlicki
May 31, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark H Wilcox
Jan 23, 2013·Journal of Critical Care·Peter M DodekHubert Wong
Mar 21, 2015·Journal of Critical Care·E BouzaE Reigadas
Aug 11, 2016·PloS One·Jen-Chieh LeeWen-Chien Ko
Nov 4, 2016·The American Journal of Gastroenterology·David M FaleckDaniel E Freedberg
Jun 20, 2013·Infection·L SabauO Leroy
Sep 28, 2018·BMC Anesthesiology·Maximilian VondranThomas Schroeter