Clostridium difficile-associated disease: an emerging threat to patient safety: insights from the Society of Infectious Diseases Pharmacists

Pharmacotherapy
Robert C Owens

Abstract

A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as several countries in Europe, being affected, all in such a short period of time. Also of note is that nontraditional hosts (e.g., otherwise healthy, noninstitutionalized persons residing in the community, some without antimicrobial exposure) have been reported to have severe disease. Data suggest that certain virulence characteristics may be responsible for more severe clinical presentations and poor outcomes. These factors (e.g., hypertoxin production, hypersporulation, antimicrobial resistance) possessed by a previously uncommon strain of C. difficile, in conjunction with particular host and environmental factors, may have precipitated the now widespread establishment of this pathogen. Antimicrobial intervention has traditionally been a mainstay of combating C. difficile-associated disease. Efforts to combat BI/NAP1 should include good antimicrobial stewardship in addition to effective infection control and environ...Continue Reading

References

Jan 26, 1989·The New England Journal of Medicine·L V McFarlandW E Stamm
Nov 1, 1987·Postgraduate Medical Journal·P J Bingley, G M Harding
Mar 1, 1982·The British Journal of Surgery·G A MoggM R Keighley
Aug 1, 1995·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·D N GerdingJ Silva
Nov 1, 1994·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·K BettinD N Gerding
Jun 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E MulliganR Y Kwok
Sep 21, 1996·Lancet·M H Wilcox
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Johnson, D N Gerding
Jun 18, 1998·The Journal of Antimicrobial Chemotherapy·M H Wilcox
Oct 20, 1998·The Journal of Hospital Infection·G E Bignardi
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J L MayfieldL M Mundy
Oct 3, 2001·Microbes and Infection·L GinaldiM De Martinis
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna WanahitaDaniel M Musher
Jul 11, 2002·Intensive Care Medicine·Thierry LhermClaire Malbrunot
Jul 24, 2002·The American Journal of Gastroenterology·Lynne V McFarlandChristina M Surawicz
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anucha ApisarnthanarakLinda M Mundy
May 15, 2003·The Journal of Antimicrobial Chemotherapy·Claudia ThomasThomas V Riley
Jun 5, 2003·Emerging Infectious Diseases·Margaret E McCuskerMary-Claire Roghmann
Jul 12, 2003·The Journal of Hospital Infection·R CunninghamN Gaunt
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Christina M Surawicz
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Minna K SalminenAsko Järvinen
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert GaynesFred C Tenover
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N Gerding
Apr 28, 2004·The Journal of Hospital Infection·S King
May 28, 2004·The Journal of Antimicrobial Chemotherapy·Mark H WilcoxOliver Corrado
Jul 9, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sandra DialDick Menzies
Aug 12, 2004·Pharmacotherapy·Robert C OwensUNKNOWN Society of Infectious Diseases Pharmacists
Sep 1, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinDaniel Chouinard
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John Mohr
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Catherine McEllistremL Zheng
Jan 28, 2005·Journal of Medical Microbiology·Lynne V McFarland
Mar 2, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Laura Eggertson
Mar 31, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Carlene A MutoLee H Harrison
Apr 16, 2005·Clinical Microbiology Reviews·Daniel E Voth, Jimmy D Ballard
Apr 27, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Erica Weir, Ken Flegel

❮ Previous
Next ❯

Citations

Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C OwensCarlene A Muto
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N GerdingRobert C Owens
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N GerdingRobert C Owens
Sep 15, 2011·Gastroenterology Research and Practice·Preetika SinhLaura Yun
Jun 17, 2008·Critical Care : the Official Journal of the Critical Care Forum·Robert C Owens
Mar 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Philip George, Andrew M Morris
Mar 25, 2008·Therapeutics and Clinical Risk Management·Philip GiordanoJason Kubert
Jul 31, 2007·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Amy Pakyz
Oct 17, 2008·Expert Opinion on Investigational Drugs·Joseph GuilesXicheng Sun
Nov 17, 2012·The Surgical Clinics of North America·Peter J Rossi, Charles E Edmiston
Aug 12, 2009·Infectious Disease Clinics of North America·Robert C Owens
Aug 25, 2009·Gastroenterology Clinics of North America·Barbara J Zarowitz
Apr 4, 2008·Diagnostic Microbiology and Infectious Disease·Robert C Owens
Sep 11, 2007·The Journal of Infection·Luis A Marcos, Herbert L DuPont
Feb 13, 2007·Diagnostic Microbiology and Infectious Disease·Robert C Owens, Paul G Ambrose
Jan 31, 2012·British Journal of Clinical Pharmacology·Daniel SuissaPaul Brassard
Mar 21, 2012·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Erik Dubberke
Jul 1, 2008·The American Journal of Medicine·Phillip J Baker
Aug 25, 2015·World Journal of Emergency Surgery : WJES·Massimo SartelliPierluigi Viale
Apr 17, 2015·Scandinavian Journal of Gastroenterology·Nagham KhanaferPhilippe Vanhems
Oct 10, 2013·International Journal of Antimicrobial Agents·Simon W LamSeth R Bauer
Sep 10, 2013·Infectious Disease Clinics of North America·Dallas G Hoover, Alexander Rodriguez-Palacios
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jason M Hollander, Jeffrey I Mechanick
Nov 23, 2006·The Annals of Pharmacotherapy·Tomasz Z JodlowskiIgor Melnychuk
Dec 11, 2008·The Annals of Pharmacotherapy·Jason C GallagherChristina Rose
Feb 27, 2018·Annals of the New York Academy of Sciences·Valerie J McKenzieReid N Harris
Oct 16, 2008·The American Journal of Gastroenterology·M Raffat JaberMark E Reeves
Jul 2, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Edward H Eiland
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynne V McFarlandGregory J Raugi
Mar 13, 2019·World Journal of Emergency Surgery : WJES·Massimo SartelliFausto Catena
Dec 7, 2006·The Annals of Pharmacotherapy·Dorothy SurowiecCristina E Cicogna
May 17, 2021·International Journal of Antimicrobial Agents·Matthew P WylieColin P McCoy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jacques PepinIsabel Brazeau
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Philip CarlingMichael Barza
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Robert C Owens, Paul G Ambrose
© 2021 Meta ULC. All rights reserved