Clostridium difficile heterogeneously impacts intestinal community architecture but drives stable metabolome responses

The ISME Journal
David RojoAndrés Moya

Abstract

Clostridium difficile-associated diarrhoea (CDAD) is caused by C. difficile toxins A and B and represents a serious emerging health problem. Yet, its progression and functional consequences are unclear. We hypothesised that C. difficile can drive major measurable metabolic changes in the gut microbiota and that a relationship with the production or absence of toxins may be established. We tested this hypothesis by performing metabolic profiling on the gut microbiota of patients with C. difficile that produced (n=6) or did not produce (n=4) toxins and on non-colonised control patients (n=6), all of whom were experiencing diarrhoea. We report a statistically significant separation (P-value <0.05) among the three groups, regardless of patient characteristics, duration of the disease, antibiotic therapy and medical history. This classification is associated with differences in the production of distinct molecules with presumptive global importance in the gut environment, disease progression and inflammation. Moreover, although severe impaired metabolite production and biological deficits were associated with the carriage of C. difficile that did not produce toxins, only previously unrecognised selective features, namely, choline- a...Continue Reading

References

Mar 1, 1982·The Journal of Clinical Investigation·T YoshimasaH Imura
Jan 1, 1994·Gut·G K Grimble
Feb 13, 2001·Developmental and Comparative Immunology·M Salzet, A Tasiemski
Jan 28, 2003·Progress in Lipid Research·Christian SohlenkampOtto Geiger
Mar 15, 2003·Journal of Neuro-oncology·Gitae YoonIn-Hong Choi
Dec 10, 2003·Microbiology·Fernando Martínez-MoralesOtto Geiger
Dec 14, 2005·Applied and Environmental Microbiology·R P Kiene
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Dec 7, 2007·Journal of Proteome Research·Jasmina SaricElaine Holmes
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Nov 14, 2008·Nucleic Acids Research·J R ColeJ M Tiedje
Jul 9, 2009·Journal of Lipid Research·Bo TanJ Michael Walker
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mary C ReaR Paul Ross
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R SwannElaine Holmes
Sep 17, 2010·Nature·Sarah A KuehneNigel P Minton
Mar 17, 2011·Nature Reviews. Microbiology·Aymé SporRuth Ley
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Dec 20, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Lisa LongatoSuzanne M de la Monte
Mar 10, 2012·The Journal of Nutritional Biochemistry·Carlos Gómez-GallegoRafael Frias
Nov 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Smaranda Craciun, Emily P Balskus
Dec 14, 2012·Gut·Ana Elena Pérez-CobasAndrés Moya
Oct 2, 2013·BioMed Research International·Krzysztof KurekMałgorzata Zendzian-Piotrowska
Dec 18, 2013·Future Microbiology·Thomas J BorodyAmit Kapur
Feb 8, 2014·Gastroenterology·Robert A Britton, Vincent B Young
May 23, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabel Bondia-PonsMatej Orešič
Oct 14, 2014·Frontiers in Microbiology·Ana E Pérez-CobasAmparo Latorre

❮ Previous
Next ❯

Citations

Mar 22, 2016·Trends in Microbiology·Andrés Moya, Manuel Ferrer
Jul 20, 2016·EBioMedicine·Sergio Serrano-VillarManuel Ferrer
Aug 16, 2016·Leukemia Research·Alessandro AllegraCaterina Musolino
Sep 20, 2016·Biochemical Pharmacology·Manuel FerrerAndrés Moya
Jun 13, 2017·Electrophoresis·Manuel FerrerDavid Rojo
Nov 11, 2017·FEMS Microbiology Ecology·Leonardo MancabelliMarco Ventura
Apr 17, 2019·Antimicrobial Agents and Chemotherapy·T J De WolfeN Safdar
Nov 12, 2019·The FEBS Journal·Jordi Mayneris-Perxachs, José-Manuel Fernández-Real
Jan 1, 2015·Antibiotics·Ana Elena Pérez-CobasAmparo Latorre
Oct 17, 2017·Current Opinion in HIV and AIDS·Sergio Serrano-VillarManuel Ferrer
Apr 25, 2018·Nature Microbiology·Andrew J HryckowianJustin L Sonnenburg
Dec 5, 2020·Journal of Pharmaceutical and Biomedical Analysis·Maria Muñoz-BenaventAmparo Latorre
Dec 21, 2016·Current Opinion in Microbiology·Andrew J HryckowianJustin L Sonnenburg
Mar 31, 2021·Critical Reviews in Food Science and Nutrition·Karolinny Cristiny de Oliveira VieiraLizziane Kretli Winkelstroter Eller
Jun 2, 2021·Metabolomics : Official Journal of the Metabolomic Society·Anna KubackaManuel Ferrer
Oct 19, 2019·Analytical Chemistry·Carolina González-RianoCoral Barbas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.