Clostridium difficile Infection Is More Severe When Toxin Is Detected in the Stool than When Detected Only by a Toxigenic Culture

Internal Medicine
Hiroyuki ShimizuNoboru Yoshimoto

Abstract

Clostridium difficile infection (CDI) is the major cause of antibiotic-associated diarrhea in hospital inpatients. Rapid testing for the toxins in stool specimens is inconclusive due to its low sensitivity. Therefore, a two-step method is recommended as the most appropriate approach. The purpose of the present study was to evaluate the differences in the disease severity score between the patients who were glutamate dehydrogenase (GDH)-positive/enzyme immunoassays (EIA) toxin-positive (group A) and those who were GDH-positive/EIA toxin-negative, but who were nonetheless finally confirmed to be toxin-positive by toxigenic culture testing (group B). A rapid detection EIA for GDH and toxin A/B were simultaneously performed for initial screening. Subsequently, the toxin production by bacterial colonies in culture was retested with the same rapid test kit when necessitated by an equivocal result of the initial screening. A total of 334 fecal specimens were evaluated. Group A consisted of 25 specimens (from 16 patients) and group B consisted of 27 specimens (from 12 patients). The severity score (based on a number of factors, including age, body temperature, serum albumin level and white cell count) of group A and B was 2.2±0.7 and 1...Continue Reading

References

Feb 1, 2002·The New England Journal of Medicine·John G Bartlett
Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fred A ZarMelinda B Davis
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N GerdingRobert C Owens
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Oct 27, 2009·Anaerobe·Monica L Schmidt, Peter H Gilligan
Feb 16, 2010·The Journal of Hospital Infection·S S GhantojiK W Garey
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Oct 29, 2010·Journal of Clinical Microbiology·Mark H WilcoxPeter Gilligan
Dec 7, 2013·World Journal of Gastroenterology : WJG·Nagham KhanaferPhilippe Vanhems

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Citations

Jun 16, 2017·Journal of Clinical Microbiology·Fiona SenchynaNiaz Banaei
Feb 15, 2018·Infectious Diseases and Therapy·Thomas V Riley, Tomomi Kimura
Sep 23, 2020·ACS Infectious Diseases·David M LyerlyGlenn S Tillotson

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