Clostridium spores for tumor-specific drug delivery

Anti-cancer Drugs
S NuytsJ Anné

Abstract

Insufficient blood supply of rapidly growing tumors leads to the presence of hypoxia, a well-known feature in solid tumors. Hypoxia is known to decrease the efficiency of currently used anti-cancer modalities like surgery, chemotherapy and radiotherapy. Therefore, hypoxia seems to be a major limitation in current anti-cancer therapy. The use of non-pathogenic clostridia to deliver toxic agents to the tumor cells takes advantage of this unique physiology. These strictly anaerobic, Gram-positive, spore-forming bacteria give, after systemic administration, a selective colonization of hypoxic/necrotic areas within the tumor. Moreover, they can be genetically modified to secrete therapeutic proteins like cytosine deaminase or tumor necrosis factor-alpha. The specificity of this protein delivery system can be further increased when expression is controlled by the use of a radio-inducible promoter, leading to increased spatial and temporal regulation of protein expression. This approach of bacterial vector systems to target protein expression to the tumor can be considered very safe since bacteria can be eliminated at any moment by the addition of proper antibiotics. The Clostridium-based delivery system thus presents an alternative t...Continue Reading

References

Jan 1, 1978·Acta neurochirurgica·F Heppner, J R Möse
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R DattaD W Kufe
Jan 1, 1990·Annual Review of Microbiology·R V Miller, T A Kokjohn
May 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·H Schlechte, B Elbe
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D YoungR P Hill
Aug 1, 1995·Nature Medicine·D E HallahanR R Weichselbaum
Jul 1, 1993·Molecular & General Genetics : MGG·H DargatzD von Wettstein
May 1, 1997·Nature Medicine·G U DachsA L Harris
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·K GeX Liu
Apr 11, 2000·Gene Therapy·B MarplesG P Margison
Apr 11, 2000·International Journal of Radiation Biology·P LambinJ Fowler
Jul 14, 2000·The Journal of Gene Medicine·M AghiX O Breakefield
Feb 15, 2001·FEMS Immunology and Medical Microbiology·J TheysP Lambin
Sep 26, 2001·Applied and Environmental Microbiology·S NuytsJ Anné

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Citations

Sep 11, 2003·The Lancet Oncology·John M PawelekDavid Bermudes
Sep 2, 2008·Current Opinion in Biotechnology·Adam T St JeanNeil S Forbes
Jan 18, 2007·European Journal of Cancer Care·I Brook
Sep 26, 2006·Peptides·Crispin R Dass, Peter F M Choong
Aug 11, 2006·Medical Hypotheses·Hassan TirandazAzam Eslamifar
Mar 30, 2007·Radiation Research·Anna S E LjungkvistAlbert J van der Kogel
Jun 14, 2005·Biochimica Et Biophysica Acta·Mickaël DesvauxIan R Henderson
Oct 23, 2004·Cancer Gene Therapy·Surren A SoghomonyanDavid Bermudes
Dec 22, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rachel M RyanClaire E Lewis
Feb 14, 2006·Biotechnology and Bioengineering·Rachel W Kasinskas, Neil S Forbes
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Oct 4, 2015·The Biochemical Journal·Elsie M WilliamsDavid F Ackerley

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