PMID: 9537207Apr 16, 1998Paper

Closure of tracheoesophageal fistulas with chemotherapy and radiotherapy

American Journal of Clinical Oncology
H F AhmedR G Wadleigh

Abstract

In patients who have esophageal cancer with a tracheoesophageal fistula, chemotherapy and radiotherapy are usually contraindicated because it is thought to enlarge the fistula. The records of 50 patients who had esophageal cancer and received simultaneous chemotherapy and radiotherapy from January 1992 to January 1997 were evaluated in the Medical Oncology Section of the Veterans Administration Medical Center, Washington, D.C. All patients were staged radiographically and endoscopically. Four patients developed a tracheoesophageal fistula while receiving treatment. One patient developed a fistula before treatment and another patient developed a fistula after treatment. Closure of the tracheoesophageal fistulas was achieved in 4 of 5 patients who responded to therapy and in those who developed fistulas before or during therapy. One of the patients whose fistula did not close died during therapy, whereas the other who developed a fistula after therapy underwent stenting. This finding indicates that development of a tracheoesophageal fistula is not a contraindication to chemotherapy and radiotherapy, and patients who are responsive to therapy may have closure of their fistulas.

References

Jun 1, 1978·The Annals of Thoracic Surgery·D M LolleyH C Urschel
Dec 1, 1991·The Annals of Thoracic Surgery·M BurtV W Rusch
Mar 1, 1973·The British Journal of Surgery·G B Ong
Jun 1, 1980·American Journal of Surgery·R H Belsey
Mar 15, 1984·Cancer·A G LittleD B Skinner
Apr 1, 1984·The Annals of Thoracic Surgery·A Duranceau, G G Jamieson
Jul 1, 1995·The Annals of Thoracic Surgery·K Wong, P Goldstraw
Sep 1, 1994·The American Journal of the Medical Sciences·E S NylenR G Wadleigh
Nov 1, 1995·Gut·R P Sturgess, A I Morris

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Citations

Jan 16, 2004·Current Treatment Options in Gastroenterology·Shailendra S. Chauhan, John D. Long
Jan 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yasumasa NishimuraNorio Mitsuhashi
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Ryuta KoikeToru Shibata
Jun 27, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yassar A QureshiHelen Booth

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