Clot perviousness is associated with first pass success of aspiration thrombectomy in the COMPASS trial.

Journal of Neurointerventional Surgery
Maxim MokinJ Mocco

Abstract

Clot density (Hounsfield units, HU) and perviousness (post-contrast increase in the HU of clot) are thought to be associated with clot composition. We evaluate whether these imaging characteristics were associated with angiographic outcomes of aspiration and stent retriever thrombectomy in COMPASS: a trial of aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion. Clot density and perviousness were measured by two independent operators who were blind to all the final angiographic and clinical outcomes. The association of clot density and perviousness with the Thrombolysis In Cerebral Infarction (TICI) scale after first pass was assessed using univariate and multivariate analysis. Among all patients enrolled in COMPASS, 165 were eligible for the post-hoc analysis (81 patients in the aspiration first and 84 in the stent retriever first groups). Overall mean perviousness of clot was significantly higher in patient with mTICI 2b-3 after first pass (28.6±22.9 vs 20.3±19.2, p=0.017). Mean perviousness among patients who achieved TICI 2c/3 versus TICI 2b versus TICI 0-2a in the aspiration first group varied significantly (32.6±26.1, 35.3±24.4, and 17.7±13.1, p=0.013). The associat...Continue Reading

References

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Citations

Jan 24, 2021·Journal of Neurointerventional Surgery·Uta HanningHelge Kniep
Feb 13, 2021·Journal of Neurointerventional Surgery·Yong-Hong DingRamanathan Kadirvel
Jul 21, 2021·Stroke; a Journal of Cerebral Circulation·Manon KappelhofUNKNOWN HERMES Collaborators
Jul 26, 2021·Clinical Neurology and Neurosurgery·Gengfan YeDaming Wang
Sep 1, 2021·Clinical Neuroradiology·Nebiyat F BelachewPasquale Mordasini

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