Clotrimazole as a Cancer Drug: A Short Review

Medicinal Chemistry
S KadavakolluS White

Abstract

Although clotrimazole was first used against fungal infections, a body of research was later developed indicating that this drug has anticancer properties as well. The mechanism of action is based on the inhibition of mitochondrial-bound glycolytic enzymes and calmodulin, which starves cancer cells of energy. Clotrimazole and its derivatives have been shown to decrease rates of cancer cell proliferation, induce G1 phase arrest, and promote pro-apoptotic factors, which lead to cell death.

Citations

Mar 23, 2017·Scientific Reports·Aldo Segura-CabreraKakajan Komurov
Oct 7, 2017·Journal of Medical Microbiology·Thalita GaginiSonia Rozental
Apr 24, 2018·Frontiers in Chemistry·Andrea MagrìVito De Pinto
Jun 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patricia Garcia FerreiraVitor Francisco Ferreira
Jun 3, 2021·International Journal of Molecular Sciences·Maria BialikEwa Oledzka

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