Clotting activation and impairment of fibrinolysis in malignancy

Thrombosis Research
E RochaJ Rifón

Abstract

Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. Results showed a significant increase of thrombin-antithrombin complexes, fibrinopeptide A (FPA) and fibrin monomers in the group of patients (p less than 0.001). There was also a significant prolongation of euglobulin lysis time (p less than 0.005) and an increase of plasminogen activator inhibitor activity (p less than 0.0001), fibrinogen degradation products (p less than 0.001), and D-dimer (p less than 0.05) in the group of patients as compared to controls; FPA levels were also increased in patients with metastases (p less than 0.005). This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in patients with malignancy.

References

Nov 1, 1979·European Journal of Biochemistry·W W Fish, I Björk
Aug 1, 1979·British Journal of Cancer·L CuratoloN Semeraro
Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·E L Wilson, E Dowdle
May 15, 1977·International Journal of Cancer. Journal International Du Cancer·B NagyB Brdar
Oct 20, 1975·Biochimica Et Biophysica Acta·W G Owen
Nov 1, 1975·Journal of Clinical Pathology·J A Rennie, D Ogston
Aug 1, 1986·The Journal of Clinical Investigation·M P BevilacquaD J Loskutoff
May 1, 1987·British Journal of Haematology·J C KirchheimerB R Binder
Jan 1, 1974·Annals of the New York Academy of Sciences·S J Slichter, L A Harker
May 1, 1984·European Journal of Cancer & Clinical Oncology·M J Duffy, P O'Grady
Jan 1, 1984·Seminars in Thrombosis and Hemostasis·L A Moroz
Oct 1, 1982·Seminars in Thrombosis and Hemostasis·R L Bick
May 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C GroppK Havemann
Feb 1, 1980·British Journal of Haematology·M B Donati, A Poggi
Oct 1, 1952·Archives of Biochemistry and Biophysics·T ASTRUP, S MULLERTZ
Jan 1, 1952·Cancer·H J TAGNONN R SHULMAN

❮ Previous
Next ❯

Citations

Nov 1, 1992·Cancer Metastasis Reviews·H C Kwaan
May 25, 2001·International Journal of Hematology·A Falanga, M B Donati
Aug 30, 2001·Critical Care Clinics·M T DeSancho, J H Rand
Dec 1, 1991·Archives of Disease in Childhood·G BalakrishnanB Gibson
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C FlösselM Müller
Jan 1, 1993·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A SagripantiB Grassi
Apr 1, 1996·Hematology/oncology Clinics of North America·K E Goad, H R Gralnick
May 30, 2002·The American Journal of Medicine·Roger E G SchutgensDouwe H Biesma
Mar 31, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S P CavanaghS Homer-Vanniasinkam
Mar 12, 2003·Hematology/oncology Clinics of North America·Hau C Kwaan, Chadi Nabhan
Jan 1, 1992·Thrombosis Research·B Kemkes-MatthesH G Lasch
Dec 15, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alexander E KoganAlexey G Katrukha
Feb 24, 2001·Equine Veterinary Journal. Supplement·L MonrealM Monreal
Jul 16, 1993·Cancer Letters·D F AlonsoE Bal de Kier Joffé
Oct 1, 1990·La Ricerca in Clinica E in Laboratorio·D Prisco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.