Clotting disorders and preeclampsia

Annales Françaises D'anesthèsie Et De Rèanimation
A-S Ducloy-Bouthors


Clotting disorders are associated with the severe, early and complicated forms of PE. Compensated hypercoagulability states associated with a thrombocytopenia (PLT<150k/mm(3)) affect 25 to 50% of severe PE patients. Laboratory markers of platelet and endothelial activation are the early increase of fibronectin levels, the worsening of the thrombocytopenia and the raised platelet turnover. The excessive thrombin formation is physiologically compensated by a rise in thrombin-antithrombin (TAT) complex levels, which is the most specific marker of a PE pregnancy, and a decrease in anti-thrombin (AT) activity. The placenta induced depression of the fibrinolysis appears to contribute towards the hypercoagulable state. The etiological importance of the erythrocyte and leucocyte activation with regards to the abnormal clotting activation is highlighted in the setting of maternal systematic inflammatory disease. The state of compensated coagulopathy found in the PE patient can suffer a pro-coagulatory imbalance because of a quantitative, or a qualitative failure (i.e. thrombophilia) of the physiological coagulation inhibitors, or a combination of both. This disseminated intravascular coagulation, qualified as chronic, is associated with...Continue Reading


Nov 1, 1979·The Journal of Clinical Investigation·H L NosselR E Canfield
Sep 1, 1975·British Journal of Obstetrics and Gynaecology·P W HowieC D Forbes
Feb 1, 1992·American Journal of Obstetrics and Gynecology·V C BallegeerA M Criel
Jun 11, 1992·Clinical Obstetrics and Gynecology·K G Perry, J N Martin
Jan 1, 1991·Gynecologic and Obstetric Investigation·T TeraoY Takeda
Jun 1, 1990·British Journal of Obstetrics and Gynaecology·A ReinthallerG Tatra
Oct 1, 1990·American Journal of Obstetrics and Gynecology·V L KatzW A Bowes
Jan 1, 1989·American Journal of Obstetrics and Gynecology·K de BoerP E Treffers
Mar 1, 1985·Clinical Obstetrics and Gynecology·G Sher, B E Statland
Nov 1, 1987·Obstetrics and Gynecology·F Mimouni, M Miodovnik
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·L Tengborn, T Bengtsson
Aug 15, 1986·Thrombosis Research·K D FriedmanJ Owen
May 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H GraeffR Schröck
Mar 1, 1982·British Journal of Haematology·T C InglisA J Davies
Feb 1, 1984·British Journal of Obstetrics and Gynaecology·F DaffosM Capella Pavlovsky
Apr 15, 1984·American Journal of Obstetrics and Gynecology·G H WeeninkJ W Ten Cate
Feb 1, 1982·British Journal of Obstetrics and Gynaecology·J ThorburnC R Whitfield
Nov 1, 1981·British Journal of Obstetrics and Gynaecology·C Giles, T C Inglis
Sep 15, 1981·Thrombosis Research·S A Cederholm-WilliamsA R Wilkinson
Oct 1, 1995·American Journal of Obstetrics and Gynecology·G A DekkerH P van Geijn
Oct 1, 1994·American Journal of Obstetrics and Gynecology·S P SeligmanS B Abramson
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·A HalliganJ Walshe
Mar 1, 1994·British Journal of Obstetrics and Gynaecology·L A NorrisJ Bonnar
Jan 1, 1994·American Journal of Obstetrics and Gynecology·H M RinderB R Smith
Oct 5, 1996·Lancet·F E PrestonF J van der Meer
Aug 1, 1996·British Journal of Anaesthesia·C E OrlikowskiS Byrne
Oct 1, 1996·American Journal of Obstetrics and Gynecology·D S Dizon-TownsonK Ward
Dec 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D M PaternosterM Plebani

❮ Previous
Next ❯


Sep 10, 2013·Indian Journal of Pharmacology·Shuang-Qing LiuShu-Hong Lei
Jun 4, 2013·Revista española de anestesiología y reanimación·C L ErrandoM Vila-Montañés
May 24, 2011·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Eduardo TejeraIrene Rebelo
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.