Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B

The Cochrane Database of Systematic Reviews
K StobartJ K Wu

Abstract

People with severe hemophilia A or B, X-linked bleeding disorders due to decreased blood levels of coagulants, suffer recurrent bleeding into joints and soft tissues. Before clotting factor concentrates were available, most people with severe hemophilia developed crippling musculoskeletal deformities. Clotting factor concentrate prophylaxis aims to preserve joint function by converting severe hemophilia (factor VIII or IX less than 1%) into a clinically milder form of the disease. Prophylaxis has long been used in Sweden, but not universally adopted because of medical, psychosocial, and cost controversies. Use of clotting factor concentrates is the single largest predictor of cost in treating hemophilia. To determine the effectiveness of clotting factor concentrate prophylaxis in the management of people with hemophilia A or B. We searched the Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references from comprehensive electronic database searches and handsearches of journals and abstract books. Reference lists of relevant articles were reviewed. Most recent search: November 2005. Randomized controlled trials (RCTs) evaluating people with severe hemophilia A or B, receiving prophylactic clotting factor...Continue Reading

Citations

Apr 26, 2008·Internal and Emergency Medicine·Alfonso IorioAndrea A Conti
Nov 3, 2015·Expert Opinion on Biological Therapy·Mark A BrimbleAndrew M Davidoff
Nov 28, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·S W Pipe, L A Valentino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.