Abstract
Acetaldehyde, the major cytotoxin formed by the metabolism of alcohol, is responsible for liver injury, extracellular matrix alterations, inflammation, and hangover in heavy drinkers. This study aimed to demonstrate the efficacy of a standardized polyphenolic extract of clove buds (Clovinol) in ameliorating the oxidative stress and inflammation caused by the accumulation of acetaldehyde after binge drinking. We used a randomized, double-blinded crossover study with 16 male social drinkers. The subjects were randomized into two groups of eight subjects and received either placebo or Clovinol in a single hard shell gelatin capsule (250 mg × 1) per day. The dosage of alcohol was 1 g/kg body weight/day. After 2 weeks of washout period, the treatment regime was reversed. Blood samples were drawn at 0, 0.5, 2, 4, and 12 h after treatment with either placebo or Clovinol, and biochemical parameters were analyzed. Hangover severity score was determined by using a validated questionnaire as reported earlier. Results showed faster elimination of blood acetaldehyde with significant decreases in oxidative stress, lipid peroxidation, C-reactive protein, interleukin-6, and significant enhancement in glutathione and superoxide dismutase as com...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 14, 2006·Addictive Behaviors·Damaris J RohsenowTimothy A Roehrs
Apr 5, 2007·Nature Protocols·Irfan RahmanSaibal K Biswas
Jan 1, 2008·Molecular Aspects of Medicine·Tommaso MelloAndrea Galli
Mar 25, 2009·Journal of Clinical Biochemistry and Nutrition·Noriko SakanoKeiki Ogino
Mar 17, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stuart F W KendrickChris P Day
Aug 18, 2010·Current Drug Abuse Reviews·Renske PenningJoris C Verster
Aug 30, 2011·Journal of Analytical Toxicology·Nicholas B TiscioneXiaoqin Shan
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Sep 26, 2012·Psychopharmacology·Renske PenningJoris C Verster
Oct 30, 2012·Clinics in Liver Disease·Arthur I Cederbaum
Apr 16, 2013·Human & Experimental Toxicology·J SchlatterP Chariot
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Diego Francisco Cortés-RojasWanderley Pereira Oliveira
Oct 31, 2014·World Journal of Gastroenterology : WJG·Alba RoccoGerardo Nardone
Oct 31, 2014·World Journal of Gastroenterology : WJG·Emilio González-ReimersGeraldine Quintero-Platt
Jan 22, 2015·Food & Function·Abin IssacI M Krishnakumar
Jul 21, 2015·Neuroscience·A G KaradayianS Lores-Arnaiz
Aug 15, 2015·Food & Function·Johannah NmKrishnakumar Im
Feb 9, 2017·Current Drug Abuse Reviews·Celeste T TippleAndrew Scholey
Apr 8, 2016·Toxicology Reports·Liju VijayasteltarKrishnakumar I M
Citations
Jan 18, 2020·Biomolecules·Martin KelloJan Mojzis
Jul 2, 2020·The Cochrane Database of Systematic Reviews·Sara TasnimJames M Wright
Aug 19, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C J Peter ErikssonJussi Kauhanen
Jun 21, 2020·International Journal of Environmental Research and Public Health·Marlou MackusJoris C Verster
Jul 8, 2020·Journal of Clinical Medicine·Aurora J A E van de LooJoris C Verster
Oct 30, 2020·Journal of Clinical Medicine·Marlou MackusJoris C Verster
May 1, 2021·Healthcare·Aurora Jae van de LooJoris C Verster