Clove Bud Polyphenols Alleviate Alterations in Inflammation and Oxidative Stress Markers Associated with Binge Drinking: A Randomized Double-Blinded Placebo-Controlled Crossover Study

Journal of Medicinal Food
Renny Reji MammenKrishnakumar Illathu Madhavamenon

Abstract

Acetaldehyde, the major cytotoxin formed by the metabolism of alcohol, is responsible for liver injury, extracellular matrix alterations, inflammation, and hangover in heavy drinkers. This study aimed to demonstrate the efficacy of a standardized polyphenolic extract of clove buds (Clovinol) in ameliorating the oxidative stress and inflammation caused by the accumulation of acetaldehyde after binge drinking. We used a randomized, double-blinded crossover study with 16 male social drinkers. The subjects were randomized into two groups of eight subjects and received either placebo or Clovinol in a single hard shell gelatin capsule (250 mg × 1) per day. The dosage of alcohol was 1 g/kg body weight/day. After 2 weeks of washout period, the treatment regime was reversed. Blood samples were drawn at 0, 0.5, 2, 4, and 12 h after treatment with either placebo or Clovinol, and biochemical parameters were analyzed. Hangover severity score was determined by using a validated questionnaire as reported earlier. Results showed faster elimination of blood acetaldehyde with significant decreases in oxidative stress, lipid peroxidation, C-reactive protein, interleukin-6, and significant enhancement in glutathione and superoxide dismutase as com...Continue Reading

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Citations

Jul 2, 2020·The Cochrane Database of Systematic Reviews·Sara TasnimJames M Wright
Aug 19, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C J Peter ErikssonJussi Kauhanen
Jun 21, 2020·International Journal of Environmental Research and Public Health·Marlou MackusJoris C Verster
Jul 8, 2020·Journal of Clinical Medicine·Aurora J A E van de LooJoris C Verster
Oct 30, 2020·Journal of Clinical Medicine·Marlou MackusJoris C Verster

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
blood collection
ELISA
MDA

Software Mentioned

Graph Pad InStatV -

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