Clove essential oil-in-cyclodextrin-in-liposomes in the aqueous and lyophilized states: From laboratory to large scale using a membrane contactor

Carbohydrate Polymers
Carine SebaalyHélène Greige-Gerges

Abstract

This work is dedicated to prepare liposomal dry powder formulations of inclusion complexes of clove essential oil (CEO) and its main component eugenol (Eug). Ethanol injection method and membrane contactor were applied to prepare liposomes at laboratory and large scale, respectively. Various liposomal formulations were tested: (1) free hydroxypropyl-β-cyclodextrin loaded liposomes; (2) drug in hydroxypropyl-β-cyclodextrin in liposomes (DCL); (3) DCL2 obtained by double loading technique, where the drug is added in the organic phase and the inclusion complex in the aqueous phase. Liposomes were characterized for their particle size, polydispersity index, Zeta potential, morphology, encapsulation efficiency of CEO components and Eug loading rate. Reproducible results were obtained with both injection devices. Compared to Eug-loaded liposomes, DCL and DCL2 improved the loading rate of Eug and possessed smaller vesicles size. The DPPH(•) scavenging activity of Eug and CEO was maintained upon incorporation of Eug and CEO into DCL and DCL2. Contrary to DCL2, DCL formulations were stable after 1 month of storage at 4°C and upon reconstitution of the dried lyophilized cakes. Hence, DCL in aqueous and lyophilized forms, are considered a...Continue Reading

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Jun 27, 2018·AAPS PharmSciTech·Marwa H Shukr, Omar A Ahmed Farid
Apr 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina ZappacostaAntonella Fontana
Jun 7, 2019·The Journal of Pharmacy and Pharmacology·Michael Adu-FrimpongJiangnan Yu
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Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Johana AndradeAmparo Chiralt
Mar 31, 2021·International Journal of Pharmaceutics·Narimane LammariAbdelhamid Elaissari
Jul 3, 2021·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Jul 24, 2021·Carbohydrate Polymers·Zuobing XiaoXingran Kou

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