Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor

The International Journal of Neuropsychopharmacology
Yuki AoyamaT Nabeshima

Abstract

Accumulating evidence suggests that dysregulation of histone modification is involved in the pathogenesis and/or pathophysiology of psychiatric disorders. However, the abnormalities in histone modification in the animal model of schizophrenia and the efficacy of antipsychotics for such abnormalities remain unclear. Here, we investigated the involvement of histone modification in phencyclidine-induced behavioral abnormalities and the effects of antipsychotics on these abnormalities. After repeated phencyclidine (10 mg/kg) treatment for 14 consecutive days, mice were treated with antipsychotics (clozapine or haloperidol) or the histone deacetylase inhibitor sodium butyrate for 7 d. Repeated phencyclidine treatments induced memory impairment and social deficit in the mice. The acetylation of histone H3 at lysine 9 residues decreased in the prefrontal cortex with phencyclidine treatment, whereas the expression level of histone deacetylase 5 increased. In addition, the phosphorylation of Ca²⁺/calmodulin-dependent protein kinase II in the nucleus decreased in the prefrontal cortex of phencyclidine-treated mice. These behavioral and epigenetic changes in phencyclidine-treated mice were attenuated by clozapine and sodium butyrate but n...Continue Reading

References

Sep 1, 1978·The American Journal of Psychiatry·R M Allen, S J Young
Oct 11, 1975·The American Journal of Psychiatry·J M Rainey, M K Crowder
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Jan 1, 1991·Journal of Clinical Psychology·J Cosgrove, T G Newell
Aug 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D JentschR H Roth
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C R YangN Gorelova
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Y NodaT Nabeshima
Mar 19, 2003·Journal of Neurochemistry·Sangeeta ChawlaHilmar Bading
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ryuichi Takahata, Bita Moghaddam
Mar 1, 1959·A.M.A. Archives of Neurology and Psychiatry·E D LUBYR KELLEY
Mar 1, 1965·Journal of Medicinal Chemistry·V H MADDOXR F PARCELL
Oct 12, 2004·Trends in Neurosciences·Georg Winterer, Daniel R Weinberger
Jan 18, 2005·Nature Reviews. Neuroscience·Jonathan M Levenson, J David Sweatt
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanUNKNOWN Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Sep 9, 2006·Nature Medicine·David A Lewis, Guillermo Gonzalez-Burgos
Apr 25, 2007·Nature Reviews. Neuroscience·Nadia TsankovaEric J Nestler
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frederick A SchroederSchahram Akbarian
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·E DongA Guidotti
Oct 2, 2008·Nature Reviews. Drug Discovery·Aleksey G Kazantsev, Leslie M Thompson
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daisuke H TanakaKazunori Nakajima
Nov 19, 2011·The International Journal of Neuropsychopharmacology·Takenao KosekiToshitaka Nabeshima
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandra B NelsonAnatol C Kreitzer

❮ Previous
Next ❯

Citations

Feb 24, 2016·Drug Development Research·Walter H MoosKosta Steliou
Jun 17, 2015·Epigenomics·Hamid Mostafavi AbdolmalekySam Thiagalingam
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yuki AoyamaKiyofumi Yamada
Feb 12, 2019·American Journal of Therapeutics·Ching-Wen Chu, Chih-Sung Liang
Apr 20, 2017·Psychopharmacology·Janitza L Montalvo-OrtizHongxin Dong
May 20, 2020·Frontiers in Psychiatry·Danielle Gouvêa-JunqueiraFernanda Crunfli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here