PMID: 375865Jun 1, 1979Paper

Clozapine, chlorpromazine, and placebo in newly hospitalized, acutely schizophrenic patients: a controlled, double-blind comparison

Archives of General Psychiatry
B ShopsinM Collora

Abstract

Clozapine is a unique compound belonging to a relatively new group of antipsychotic agents, the dibenzazepines. To our knowledge, the present study represents the first double-blind, controlled comparison recorded in the United States. The data suggest that clozapine in the present population of newly admitted, acutely psychotic schizophrenic individuals, and in the doses employed, was more effective in overall improvement response, discharge rate, and ameliorating discrete symptoms across the different objective rating scales used than was chlorpromazine (Thorazine) hydrochloride. Placebo was ineffective. Unlike chlorpromazine, no extrapyramidal reactions occurred in those patients ingesting clozapine. Clozapine was also beneficial in reversing abnormal involuntary motor movements. It is an excellent anxiolytic and hypnotic agent. Sedation, hypotension, and hypersalivation are among the more common side effects observed.

Citations

Jun 3, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·P M LlorcaJ C Scotto
Jul 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D J HealW R Buckett
Apr 3, 1999·Biological Psychiatry· AdityanjeeT Mathews
Mar 1, 1991·Pharmacopsychiatry·D Naber, H Hippius
Jul 1, 1988·Schizophrenia Research·J M HerreraC Heh
May 27, 2003·Schizophrenia Research·S Charles SchulzMartin Brecher
Oct 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·C F Saller, A I Salama
Jan 1, 1989·Psychopharmacology·D E Casey
Jan 1, 1989·Psychopharmacology·H J GaertnerJ Hoss
Jan 1, 1989·Psychopharmacology·M SchmaussE Rüther
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·G D Anderson, G V Rebec
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R D Oades
Jan 1, 1997·International Journal of Psychiatry in Clinical Practice·G JoffeR Rimon
Oct 20, 1998·Journal of Toxicology. Clinical Toxicology·T J HarmonE Cortes-Belen
Jan 1, 1997·Current Medical Research and Opinion·H Y Meltzer
Sep 22, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
Aug 1, 1990·Archives of Psychiatric Nursing·D Hamilton
Jan 1, 1981·Comprehensive Psychiatry·G L Klerman
Jan 1, 1994·Comprehensive Psychiatry·D D MillerN C Andreasen
Jun 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·L K JacobsenJ L Woolston
Jan 1, 1986·Annals of the New York Academy of Sciences·J G SmallI F Small
Oct 1, 1983·Statistics in Medicine·C J McDonaldG P McCabe
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanUNKNOWN World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia
Mar 14, 1991·The New England Journal of Medicine·R J Baldessarini, F R Frankenburg
Jan 1, 1987·Journal of the American Psychoanalytic Association·F F Loeb, L R Loeb
Nov 13, 2004·European Archives of Psychiatry and Clinical Neuroscience·Bettina S FehrTrisha Suppes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here