Clozapine-induced interstitial nephritis - a rare but important complication: a case report.

Journal of Medical Case Reports
Robert HunterSusan Shankie

Abstract

Given the limited range of effective drug treatments for patients with schizophrenia, increasing numbers of patients, often termed 'treatment-resistant' are prescribed clozapine. While the induction of neutropenia or agranulocytosis by clozapine is well appreciated, other rare potentially fatal adverse reactions may also occur including acute interstitial nephritis as reported in this case. A 57-year-old Caucasian woman with treatment-resistant chronic schizophrenia developed acute renal failure following initiation of treatment with clozapine. The adverse reaction occurred after only four doses of the drug had been administered (titrated from 12.5 to 25 mg per day). After clozapine had been withdrawn, the patient's renal function returned to normal with no other changes to medication. The patient had been exposed to clozapine about 4 years previously when she had developed a similar reaction. Renal reactions to clozapine are extremely rare but, if not recognized promptly, may prove fatal. Psychiatrists need to be aware of this possible complication when clozapine is initiated.

References

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Aug 23, 2000·The Australian and New Zealand Journal of Psychiatry·K E Southall
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Jan 30, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Robert HunterJohn Norrie

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Citations

Oct 7, 2011·The Primary Care Companion to CNS Disorders·J Daniel KanofskyElina Jerschow
Mar 6, 2012·Internal Medicine Journal·D J BowenS Braude
May 28, 2019·The Mental Health Clinician·Erica A K Davis, Deanna L Kelly

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Methods Mentioned

BETA
biopsy

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