PMID: 8968299Nov 1, 1996Paper

Clozapine-induced urinary incontinence: incidence and treatment with ephedrine

The Journal of Clinical Psychiatry
M A FullerP E Konicki

Abstract

Treatment with the atypical antipsychotic drug clozapine appears to be associated with an increased incidence of urinary incontinence (UI). We posited that the potent anti-alpha-adrenergic effects of clozapine were involved, and hence that an alpha-adrenergic agonist would reduce UI. We tested this hypothesis by using ephedrine, an approved alpha-adrenergic agonist. Fifty-seven inpatients with schizophrenia or schizoaffective disorder (DSM-IV) who met the Kane criteria for being treatment refractory were treated with clozapine (75-900 mg/day). Patients who developed UI were then openly treated with ephedrine in increasing doses until UI was attenuated or a dose of 150 mg/day was attained. Seventeen patients developed UI as evidenced by either urine-stained sheets/clothing or direct patient reports. In 2 cases, the UI was sufficiently severe that adult diapers had to be used. Comparison of patients who developed UI and those who did not showed that UI was associated with female gender and with concomitant treatment with typical antipsychotic drugs. One patient was treated with a behavioral program, but the remaining 16 patients were treated with ephedrine. Ephedrine treatment was very effective, with 15/16 patients showing impro...Continue Reading

Citations

Sep 28, 2001·Neurourology and Urodynamics·P L Vera, I Nadelhaft
Apr 27, 2010·Journal of Child and Adolescent Psychopharmacology·Fadi T Maalouf, Andrew R Gilbert
Jan 1, 2009·BMJ Case Reports·Sahoo Saddichha, Manoj Kumar
Jun 10, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Mira Harrison-WoolrychDavid C G Skegg
Jan 5, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Thomas R E BarnesCarol Paton
Jul 4, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·Mohamad Mehtar, Alp Ucok
Jul 14, 2005·Expert Opinion on Drug Safety·Joanna FitzsimonsSeetal Dodd
Jan 23, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ersin Hatice KarslıoǧluAli Çayköylü
Apr 5, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sabri Hergüner, Nahit Motavalli Mukaddes
Jul 30, 2015·Journal of Child and Adolescent Psychopharmacology·Melih Nuri Karakurt, Serkan Süren
Apr 30, 2015·The Australian and New Zealand Journal of Psychiatry·Navin Dadlani, Marni Austin
Feb 2, 2010·Journal of Korean Medical Science·Myung-Ji Lee, Chul-Eung Kim
Nov 5, 2011·Journal of Clinical Psychopharmacology·Sabri HergünerHasibe Uygun Küçükapan
Sep 10, 1999·Acta Psychiatrica Scandinavica·C C LinT H Lan
Nov 18, 2008·Journal of Clinical Psychopharmacology·Seong Hoon JeongYong Sik Kim
Jun 28, 2008·Drugs & Aging·Peter TsakirisMartin C Michel
Jan 1, 2005·International Journal of Psychiatry in Clinical Practice·Diletta La TorreMario Meduri
Mar 30, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C Stanniland, D Taylor
Oct 11, 2011·Clinical Schizophrenia & Related Psychoses·Mary V Seeman
Aug 16, 2003·Journal of Clinical Psychopharmacology·Jose de LeonGeorge M Simpson
Aug 15, 2014·Journal of Clinical Psychopharmacology·Hirokazu KumazakiMasaru Mimura
Aug 4, 2001·The Annals of Pharmacotherapy·B A EnglishS R Saklad
Sep 8, 2007·Journal of Child and Adolescent Psychopharmacology·Sabri Hergüner, Nahit Motavalli Mukaddes
Mar 19, 2016·Clinical Neuropharmacology·Joseph Mergui, Sol Jaworowski
Oct 4, 2020·Journal of Clinical Psychopharmacology·Sowmya SelvarajGanesan Venkatasubramanian
Aug 17, 2021·Journal of Clinical Pharmacology·James R Docherty, Hadeel A Alsufyani
Aug 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amin ArastehSeyede Saba Mostafavi Montazeri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.