PMID: 8938830Jan 1, 1996Paper

Clozapine plasma level monitoring: current status

The Psychiatric Quarterly
T B Cooper

Abstract

Plasma level monitoring of clozapine and metabolites may prove beneficial in treating patients who show unusual drug metabolic activity. A threshold plasma level for patients who will respond to this medication is suggested. The interaction of gender, age, smoking, other medication and side effects with plasma clozapine and metabolites are discussed. Plasma level monitoring of clozapine and/or metabolites is recommended in patients who do not respond at usual therapeutic dose, who show untoward side effects at low dose or who are treated with other medications. Finally monitoring of patients who require more than 600 mg/day should be implemented because there is evidence that the incidence of seizures increases significantly above this dosage level. There is some evidence that high plasma clozapine levels are associated with seizures.

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Citations

Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marie Jeanne HaackPhilippe A E G Delespaul
Jul 10, 2003·British Journal of Clinical Pharmacology·R J FlanaganT R E Barnes
May 4, 2011·Acta Psychiatrica Scandinavica·J NielsenD Taylor
Dec 6, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rossella MedoriGerhard Gründer
Jul 30, 2015·Thérapie·Zoubir DjeradaFréderic Libert
Feb 14, 2012·The Australian and New Zealand Journal of Psychiatry·Anne Stark, James Scott
Jul 2, 2004·Therapeutic Drug Monitoring·Christoph HiemkeMatthias J Müller
Aug 17, 2006·Harvard Review of Psychiatry·Michael T ComptonBenjamin G Druss
Jun 2, 2001·Journal of Clinical Psychopharmacology·I GaertnerK Dietz
Mar 27, 2003·Therapeutic Drug Monitoring·Sven UlrichJuergen Staedt
Feb 11, 1999·The Annals of Pharmacotherapy·J S MarkowitzT R Moore
Jun 15, 2013·Journal of Clinical Psychopharmacology·Cara A BrownAlbert H C Wong
Apr 16, 2021·Translational and Clinical Pharmacology·Joomi LeeKwang-Hee Shin

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