Clozapine reduces alcohol drinking in Syrian golden hamsters

Psychiatry Research
Alan I GreenJ J Schildkraut

Abstract

Alcohol abuse contributes substantially to the overall morbidity of schizophrenia. While typical antipsychotic medications do not limit alcohol use in patients with schizophrenia, emerging data suggest that the atypical antipsychotic clozapine does. To further elucidate the effects of these antipsychotics on alcohol use, we initiated a study in alcohol-preferring rodents. Syrian golden hamsters were given free-choice, unlimited access to alcohol. Nine days of treatment (s.c. injection) with clozapine (2-4 mg/kg/day), but not haloperidol (0.2-0.4 mg/kg/day), reduced alcohol drinking. Clozapine reduced alcohol drinking by 88% (from 11.3+/-1.7 to 1.4+/-0.2 g/kg/day) while increasing both water and food intake. Alcohol drinking gradually (during 24 days) returned toward baseline in the clozapine-treated animals when vehicle was substituted for clozapine. Further increasing the doses of haloperidol (0.6-1.0 mg/kg/day) had no effect on alcohol drinking; moreover, very low doses of haloperidol (0.025-0.1 mg/kg/day) tested in separate groups of hamsters also had no effect on alcohol drinking. This study demonstrates that clozapine, but not haloperidol, can effectively and reversibly decrease alcohol consumption in alcohol-preferring ha...Continue Reading

References

Jul 1, 1975·Journal of Studies on Alcohol·E X Freed
Oct 1, 1979·Pharmacology, Biochemistry, and Behavior·P J Kulkosky, N W Cornell
Jan 1, 1991·Schizophrenia Bulletin·S J BartelsD H Freeman
Nov 21, 1990·JAMA : the Journal of the American Medical Association·D A RegierF L Goodwin
Jul 1, 1989·The Journal of Nervous and Mental Disease·R E DrakeM A Wallach
Jan 1, 1989·Schizophrenia Bulletin·M A TestK Ripp
Oct 1, 1987·Acta Psychiatrica Scandinavica·P AllebeckB Wistedt
May 1, 1981·Journal of Studies on Alcohol·G D McCoyP C Tambone
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·I PanockaM Massi
Jun 1, 1995·The American Journal of Psychiatry·P Marcus, R Snyder
May 1, 1994·The American Journal of Psychiatry·M J AlbaneseAlan I Green
Nov 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N BrunelloG Racagni
Apr 1, 1996·The Journal of Nervous and Mental Disease·A F LehmanJ L Johnson
May 1, 1996·Schizophrenia Research·S GuptaE A Haffke
Aug 1, 1996·Psychiatric Services : a Journal of the American Psychiatric Association·R R OwenB J Cuffel
Oct 6, 1997·Alcoholism, Clinical and Experimental Research·C W HodgeA M Chappelle
May 29, 1999·Critical Reviews in Neurobiology·W J McBride, T K Li
May 4, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·V M SimónM A Aguilar
May 18, 2000·Biochemical and Biophysical Research Communications·W M KeungO Lazo
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Michelle D Lee, Peter G Clifton
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Alan I GreenKimberly Rawlins

Citations

Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Dec 2, 2008·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Paula RiggsFrank Vocci
Aug 7, 2010·Physiology & Behavior·Danielle Gulick, Alan I Green
Nov 10, 2009·Neuropharmacology·David T ChauAlan I Green
Jun 19, 2007·Journal of Substance Abuse Treatment·Alan I GreenChristopher D O'Keefe
Feb 17, 2006·European Journal of Pharmacology·Kimmo Ingman, Esa R Korpi
Sep 8, 2015·Journal of Psychiatric Research·David T ChauAlan I Green
Apr 2, 2014·Schizophrenia Research·Raquelle I Mesholam-GatelyAlan I Green
Dec 19, 2020·Drug Development Research·Alberto Ortega-VázquezNancy Monroy-Jaramillo
Dec 1, 2017·Neuropharmacology·Anel A JaramilloJoyce Besheer
Apr 20, 2021·Journal of Dual Diagnosis·Mary F Brunette

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here