PMID: 9525793Apr 3, 1998Paper

Clozapine therapy for older veterans

Psychiatric Services : a Journal of the American Psychiatric Association
M SajatovicL S Lehmann

Abstract

The effectiveness of clozapine treatment in a treatment-refractory sample of older adult veterans with primary psychosis was examined. Data were collected over a five-year period for patients age 55 and older who were given clozapine because of a history of treatment-refractory or treatment-intolerant psychosis. At initiation of clozapine therapy, baseline demographic, clinical, and psychopathology data were collected. At baseline and quarterly, patients' psychopathology was rated with the Brief Psychiatric Rating Scale (BPRS), and involuntary movements were rated with the Abnormal Involuntary Movement Scale (AIMS). The 329 patients age 55 or older who received clozapine during the study period represented 10 percent of all patients on clozapine therapy in the VA system. Of the 312 patients for whom demographic information was available, 294 were men and 18 were women. Overall, patients improved on clozapine therapy, although wide variation in drug response was observed. Complete BPRS and AIMS data were available for 97 patients. The 55- to 64-year-old group had a mean improvement in total BPRS score of 19.8 percent, with 42.6 percent showing more than a 20 percent improvement; those age 65 and older had a mean improvement of 5...Continue Reading

Citations

Jul 20, 2002·Current Psychiatry Reports·Jeremy A Sable, Dilip V Jeste
Dec 7, 2000·Advance for Nurse Practitioners·D Antai-Otong
Dec 6, 2005·The Psychiatric Clinics of North America·Aricca D Van CittersDilip V Jeste
Jul 26, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Narsimha R Pinninti, Catherine J Datto
Dec 5, 2003·Journal of Geriatric Psychiatry and Neurology·Nicholas HoehJoel Streim
Feb 24, 2001·Journal of Psychopharmacology·D M Taylor, D Duncan-McConnell
Jan 25, 2005·Drugs & Aging·Martha SajatovicNicoleta Coconcea
Aug 21, 2019·European Archives of Psychiatry and Clinical Neuroscience·Parita ShahAriel Graff-Guerrero
Jul 19, 2012·Expert Opinion on Pharmacotherapy·Eric Fakra, Jean-Michel Azorin
Feb 23, 2021·International Psychogeriatrics·Melissa Renzenbrink, Anne Pamela Frances Wand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here