Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

Journal of Neural Transmission
A E EvinsD C Goff

Abstract

To examine whether serum excitatory amino acid concentrations change with clozapine treatment and whether these changes correlate with improvement in negative symptoms, serum excitatory amino acids were measured and clinical scales administered in seven subjects with schizophrenia before and after switching from conventional neuroleptics to clozapine. Clozapine treatment was associated with increased serum glutamate and aspartate concentrations. Clinical improvement was negatively correlated with baseline glycine concentrations. These results support the hypothesis that clozapine acts at least in part by increasing glutamatergic activity.

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Citations

Jul 8, 2005·Psychopharmacology·Charles H LargeDonald C Goff
Apr 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F M M A van der HeijdenW M A Verhoeven
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Uriel Heresco-Levy
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Albert Hung Choy Wong, Hubert H M Van Tol
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Jun 27, 2002·Schizophrenia Research·A Eden EvinsDonald C Goff
Mar 7, 2006·Clinical Neuropharmacology·Constantin TranulisDavid Gourion
Oct 31, 2002·Human Psychopharmacology·Brendan Belsham
Jul 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hua-Lin CaiHai-Sen Ye
Feb 12, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sabine A FuchsTom J de Koning
Mar 24, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Donald C GoffSteven G Potkin
Mar 21, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nico J M van BeverenDurk Fekkes
Jun 15, 2011·Behavioural Brain Research·Kelly Juliana SeibtCarla Denise Bonan
Apr 17, 2012·Journal of Psychiatric Research·Jaromir HonsJan Libiger
May 3, 2000·Medical Hypotheses·D R Lara, D O Souza
Jan 5, 2010·Psychiatry Investigation·Vincenzo De LucaMarcellino Monda
Apr 12, 2017·CNS Drugs·Joshua T Kantrowitz
Jul 28, 2004·Molecular Psychiatry·D C Javitt
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky
May 15, 2002·Journal of Clinical Psychopharmacology·Floortje E ScheepersRené S Kahn
Aug 11, 2018·Frontiers in Psychiatry·Ruta SamanaiteAlice Egerton
Jan 6, 2021·Schizophrenia Bulletin·Grant McQueenAlice Egerton

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