Clozapine use in childhood and adolescent schizophrenia: A nationwide population-based study

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Carolina SchneiderS Frangou

Abstract

Early onset schizophrenia (EOS) begins in childhood or adolescence. EOS is associated with poor treatment response and may benefit from timely use of clozapine. This study aimed to identify the predictors of clozapine use in EOS and characterize the clinical profile and outcome of clozapine-treated youths with schizophrenia. We conducted a nationwide population-based study using linked data from Danish medical registries. We examined all incident cases of EOS (i.e., cases diagnosed prior to their 18th birthday) between December 31st 1994 and December 31st 2006 and characterized their demographic, clinical and treatment profiles. We then used multivariable cox proportional hazard models to identify predictors of clozapine treatment in this patient population. We identified 662 EOS cases (1.9% of all schizophrenia cases), of whom 108 (17.6%) had commenced clozapine by December 31st 2008. Patients had on average 3 antipsychotic trials prior to clozapine initiation. The mean interval between first antipsychotic treatment and clozapine initiation was 3.2 (2.9) years. Older age at diagnosis of schizophrenia [HR=1.2, 95% CI (1.05-1.4), p=0.01], family history of schizophrenia [HR=2.1, 95% CI (1.1-3.04), p=0.02] and attempted suicide [...Continue Reading

References

May 27, 2003·Schizophrenia Research·Apostolos VourdasSophia Frangou
Jun 19, 2004·Nordic Journal of Psychiatry·Håkan Jarbin, Anne-Liis Von Knorring
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Oct 13, 2005·European Child & Adolescent Psychiatry·Bernd Röpcke, Christian Eggers
Aug 10, 2006·Journal of Neural Transmission·H RemschmidtE Schulz
Jan 5, 2007·Journal of Child and Adolescent Psychopharmacology·Gal ShovalGil Zalsman
Sep 27, 2007·European Child & Adolescent Psychiatry·Nora S VyasSophia Frangou
Mar 24, 2009·Current Psychiatry Reports·Anjené M Addington, Judith L Rapoport
May 25, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Robert L FindlingLinmarie Sikich
Jun 8, 2010·Pharmacy World & Science : PWS·Jeff HarrisonAmanda J Wheeler
Jul 21, 2010·Clinical Schizophrenia & Related Psychoses·Tatiana FalconeKathleen Franco
May 28, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·B G SchimmelmannM Lambert
Jun 30, 2011·Current Psychiatry Reports·Peter GochmanJudith L Rapoport
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
Aug 4, 2011·Scandinavian Journal of Public Health·Ole MorsPreben Bo Mortensen
Aug 4, 2011·Scandinavian Journal of Public Health·Povl Munk-Jørgensen, Søren Dinesen Østergaard
Sep 8, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Oliver D HowesDavid Taylor
Sep 26, 2012·Clinical Schizophrenia & Related Psychoses·Herbert Y Meltzer
Dec 12, 2012·The Journal of Clinical Psychiatry·Vanessa Sanchez-GistauJosefina Castro-Fornieles
Aug 27, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Jon McClellanUNKNOWN American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI)
Oct 8, 2013·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Andreas HeinzUlrich Reininghaus
Oct 15, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·C SchneiderS Frangou
Nov 16, 2013·Psychiatric Services : a Journal of the American Psychiatric Association·T Scott StroupMark Olfson

❮ Previous
Next ❯

Citations

Jan 20, 2016·Journal of Child and Adolescent Psychopharmacology·Lauren I KasoffJudith L Rapoport
Feb 29, 2016·The Lancet. Psychiatry·Theresa WimberleyChristiane Gasse
Jun 16, 2016·Journal of Child and Adolescent Psychopharmacology·Hatice Aksu, Sevcan Karakoç Demirkaya
Dec 22, 2016·Journal of Child and Adolescent Mental Health·Deirdre PieterseWendy Vogel
Mar 3, 2017·Indian Journal of Psychological Medicine·Samir Kumar Praharaj
Jul 10, 2018·Early Intervention in Psychiatry·Kristen Thien, Brian O'Donoghue
Oct 26, 2018·Journal of Child and Adolescent Psychopharmacology·Laura M SteinauerJennifer L Vande Voort
Jan 26, 2018·Schizophrenia Bulletin·Johnny DownsLaura Pina-Camacho
Nov 7, 2018·The Mental Health Clinician·Ann Marie RuheDavid Procaccini
Feb 12, 2017·Schizophrenia Bulletin·Theresa WimberleyHenriette Thisted Horsdal
May 8, 2020·Pharmacoepidemiology and Drug Safety·Marieke M Beex-OosterhuisRob J van Marum
Aug 2, 2018·Therapeutic Advances in Psychopharmacology·Daniel Hayes, Marinos Kyriakopoulos
May 15, 2019·American Journal of Therapeutics·Vivekananda RachamalluManish Aligeti
May 16, 2017·Acta Psychiatrica Scandinavica·C J BachmannD Taylor
Jul 21, 2021·Journal of Child and Adolescent Psychopharmacology·Gul KaracetinYesim Saglam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Tian-Mei SiXin Yu
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
R A DicksonS J Warden
© 2021 Meta ULC. All rights reserved