May 16, 2018

ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets

Antimicrobial Agents and Chemotherapy
Hsin-Hui HuangTsuey-Ching Yang

Abstract

The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in Stenotrophomonas maltophilia The clpA, clpS, clpP, and htpX genes were upregulated in response to kanamycin exposure. Of these, clpA and htpX were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance. Inactivation of clpA and htpX compromised protease-mediated intrinsic aminoglycoside resistance and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment of S. maltophilia infections.

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Mentioned in this Paper

CLPP gene
Endopeptidase Clp Activity
Aminoglycoside [EPC]
Genes
Immunologic Adjuvants
Aminoglycosides
Bacteriocidal Agents
Adjuvant
HtpX protein, E coli
Peptide Hydrolases

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