Cluster analysis of Scedosporium boydii infections in a single hospital

International Journal of Medical Microbiology : IJMM
A BernhardtKathrin Tintelnot

Abstract

Scedosporiosis is a rare, but often fatal mycotic infection occurring in immunosuppressed as well as in immunocompetent patients. Over a period of 14 months, Scedosporium boydii isolates were sent to our reference laboratory from six immunocompetent patients treated at a single hospital in Germany. In analogy to the EORTC/MSG criteria, four patients were classified as proven invasive scedosporiosis cases, and two patients as probable or possible cases. Of note, in five patients scedosporiosis was diagnosed between 1 and 14 months (median 5.0 months) after cardiac surgery. Despite antimycotic treatment two patients died, and three were lost for long-term follow-up. All clinical S. boydii isolates were characterized by molecular analysis using multilocus sequence typing (MLST). An identical MLST type was found in five patients who had been treated in the surgery unit, suggesting a link between these infections. The source of S. boydii has not been identified. Within an observation period of 2 years before and after this cluster of infections no further cases of scedosporiosis were reported from this hospital.

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Citations

Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Mar 15, 2018·Medical Mycology·Andoni Ramirez-GarciaFernando L Hernando
Jun 13, 2018·Antimicrobial Agents and Chemotherapy·Anne BernhardtKathrin Tintelnot
Oct 10, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Carsten SchwarzKathrin Tintelnot

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