PMID: 9533291Apr 9, 1998Paper

Cluster analysis of the genetic heterogeneity and disease distributions in purebred dog populations

The Veterinary Record
G J UbbinkJ Rothuizen

Abstract

Purebred dog populations have been subject to strong selection which has resulted in extreme differences between breeds and decreased heterogeneity within breeds. As a result, breed-specific inherited diseases have accumulated in many populations. The aim of this study was to analyse genetic heterogeneity in relation to the distribution of elbow dysplasia in labrador retrievers, portosystemic shunts in Irish wolfhounds, and hepatic copper toxicosis, in Bedlington terriers. Decreased heterogeneity was demonstrated in the multiple genetic interrelations in the three populations. In pedigrees containing seven generations of ancestors, the average number of common ancestors in all pair-wise combinations of dogs was five to six (range 0 to 18). These complex interrelationships were resolved by a cluster analysis on matrices of relatedness. This analysis gave clusters of highly related animals, the average relatedness of these clusters, and the average relatedness of the entire population, as expressions of its genetic variability. The mean relatedness was 0.032 for Irish wolfhounds and Bedlington terriers, and 0.002 for labrador retrievers. The labrador retriever cohort was resolved into 31 clusters, and all cases of elbow dysplasia...Continue Reading

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Citations

Sep 2, 2005·The Journal of Heredity·J Aguirre-Hernández, D R Sargan
Aug 8, 2009·Genetics, Selection, Evolution : GSE·Pieter A OliehoekArie van der Meijden
May 21, 2013·Journal of the American Veterinary Medical Association·Thomas P BellumoriAnita M Oberbauer
Jul 23, 2003·Journal of the American Animal Hospital Association·Karen M Tobias
Nov 1, 2007·The Veterinary Quarterly·S R UrferA Steiger
Dec 8, 2009·The Veterinary Journal·Jennifer F SummersLisa M Collins
Jul 31, 2009·The Veterinary Journal·Jedee TemwichitrHerman A W Hazewinkel
Sep 8, 2011·The Journal of Small Animal Practice·J W Yeates, D C J Main
Sep 25, 2015·Canine Genetics and Epidemiology·A M OberbauerT R Famula
Jun 17, 2006·Theriogenology·Anne M TraasPaula Henthorn
Aug 11, 2001·American Journal of Veterinary Research·A L NielenB W Knol
Jun 22, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Frietson GalisMarc Nussbaumer
May 3, 2006·American Journal of Veterinary Research·Dylan N ClementsWilliam E R Ollier
Apr 9, 1998·The Veterinary Record·D L DoxeyP J Curry
May 10, 2000·The Veterinary Record·S HaywoodS J Kemp
Dec 11, 2003·Journal of the American Veterinary Medical Association·Karen M Tobias, Barton W Rohrbach
Apr 20, 2000·American Journal of Veterinary Research·O A GardenR M Batt
Feb 25, 2000·Journal of the American Veterinary Medical Association·K J FowlerR J Tassicker
Oct 2, 2003·Journal of the American Animal Hospital Association·Margaret PuccioBrian McKenna
Dec 3, 2013·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M Jansson, L Laikre
Sep 7, 2000·The Veterinary Record·G J UbbinkJ Rothuizen
Jan 8, 2021·Genetics, Selection, Evolution : GSE·Arthur M A Pistorius, Ineke Blokker

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