Cluster headache: present and future therapy

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Massimo LeoneAlberto Proietti Cecchini

Abstract

Cluster headache is characterized by severe, unilateral headache attacks of orbital, supraorbital or temporal pain lasting 15-180 min accompanied by ipsilateral lacrimation, rhinorrhea and other cranial autonomic manifestations. Cluster headache attacks need fast-acting abortive agents because the pain peaks very quickly; sumatriptan injection is the gold standard acute treatment. First-line preventative drugs include verapamil and carbolithium. Other drugs demonstrated effective in open trials include topiramate, valproic acid, gabapentin and others. Steroids are very effective; local injection in the occipital area is also effective but its prolonged use needs caution. Monoclonal antibodies against calcitonin gene-related peptide are under investigation as prophylactic agents in both episodic and chronic cluster headache. A number of neurostimulation procedures including occipital nerve stimulation, vagus nerve stimulation, sphenopalatine ganglion stimulation and the more invasive hypothalamic stimulation are employed in chronic intractable cluster headache.

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN Sumatriptan Cluster Headache Study Group
Sep 1, 1989·Cephalalgia : an International Journal of Headache·R Hering, A Kuritzky
Mar 1, 1989·Headache·I J Gabai, E L Spierings
Mar 1, 1986·Cephalalgia : an International Journal of Headache·P G Andersson, L T Jespersen
Nov 1, 1996·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
Aug 29, 2000·Cephalalgia : an International Journal of Headache·A CostaG Nappi
Jul 21, 2001·Regional Anesthesia and Pain Medicine·B A TayD C Chung
Jun 6, 2002·Cephalalgia : an International Journal of Headache·M El AmraniM G Bousser
Nov 8, 2002·Cephalalgia : an International Journal of Headache·A I M Nilsson RemahlE Waldenlind
Feb 27, 2004·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
May 20, 2004·Headache·David W DodickStephen Silberstein
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arne MayThomas R Tolle
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P CortelliP Montagna
Apr 29, 2010·Current Pain and Headache Reports·Avi Ashkenazi
Jul 21, 2012·Lancet Neurology·Delphine Magis, Jean Schoenen
Jan 15, 2013·Cephalalgia : an International Journal of Headache·Jean SchoenenArne May
Oct 23, 2013·The Journal of Headache and Pain·Paolo MartellettiUNKNOWN European Headache Federation
Apr 18, 2014·Cephalalgia : an International Journal of Headache·Tim P JürgensRigmor H Jensen
Jun 25, 2014·Cephalalgia : an International Journal of Headache·Lars NeebUwe Reuter
Feb 26, 2015·Neurology·Alexander D NesbittPeter J Goadsby
Dec 10, 2015·Cephalalgia : an International Journal of Headache·Massimo Leone, Alberto Proietti Cecchini
Dec 29, 2015·The Cochrane Database of Systematic Reviews·Michael H BennettStephanie Weibel
May 12, 2016·Cephalalgia : an International Journal of Headache·Tim P JürgensRigmor Højland Jensen
Jun 3, 2016·Cephalalgia : an International Journal of Headache·Massimo LeoneAngelo Franzini

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Citations

Apr 16, 2019·Headache·Smriti IyengarSheena K Aurora
May 6, 2019·Expert Review of Neurotherapeutics·János TajtiLászló Vécsei
Mar 17, 2018·Frontiers in Pharmacology·Emmanuelle A D SchindlerDeepak C D'Souza
Apr 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Matthew J ZiegelmannLaurence A Levine
May 21, 2020·Frontiers in Pharmacology·Natalija PopovićMiroljub Popović
Oct 10, 2020·Journal of Pharmacy Practice·Richard WenzelAlexis S Clark
Mar 6, 2019·Journal of Neurosurgery·Sérgio A F DantasClement Hamani

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