Clustered nanobody-drug conjugates for targeted cancer therapy.

Chemical Communications : Chem Comm
Tiantian WuYangzhong Liu

Abstract

A clustered Nb-drug conjugate (cNDC@PEG) was designed using anti-EGFR Nb to specifically deliver Pt(iv) prodrugs to tumors. cNDC@PEG efficiently targets EGFR positive tumor cells, and the clustered cNDC@PEG is more efficient in inhibiting tumor growth in vivo than the monomeric NDC. This work provides a novel strategy for the construction of a multi-valent NDC using dendrimers.

References

Jul 12, 2007·Genome Research·Haoyi WangRobi David Mitra
Apr 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lea Olive Tchouate GainkamTony Lahoutte
Feb 14, 2009·Nature Protocols·Juergen FriedrichLeoni A Kunz-Schughart
Apr 7, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sabrina OliveiraRob C Roovers
Jan 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shanta DharOmid C Farokhzad
Apr 27, 2011·International Journal of Cancer. Journal International Du Cancer·Rob C RooversPaul M P van Bergen en Henegouwen
Jun 25, 2013·Structure·Karl R SchmitzKathryn M Ferguson
Mar 20, 2014·Pharmaceutical Research·Srinivas GantaTimothy P Coleman
Apr 30, 2014·Chemical Communications : Chem Comm·Qinqin ChengYangzhong Liu
Jan 23, 2016·Nature Chemistry·Vijay ChudasamaStephen Caddick
Mar 25, 2017·Nature Reviews. Cancer·Philip GotwalsGlenn Dranoff
Jul 30, 2017·Nature Chemistry·Henry D HerceChristian P R Hackenberger
Dec 17, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harshad P PatilRita Vanbever
Feb 13, 2018·Nature Structural & Molecular Biology·Conor McMahonAndrew C Kruse
Feb 23, 2018·Angewandte Chemie·Els PardonJan Steyaert
Mar 4, 2018·Nature Communications·David VirantUlrich Rothbauer
May 22, 2018·Chemical Science·Benjamin J StentonGonçalo J L Bernardes
Jun 9, 2018·International Journal of Nanomedicine·Haitao PanZhong Wang
Oct 10, 2018·Chemical Reviews·Xiaohui WangZijian Guo
Feb 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tiantian WuYangzhong Liu

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Citations

Jan 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Manman LiuYangzhong Liu
May 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandeep Surendra PanikarPedro Salas
Jun 17, 2021·Cell and Tissue Research·Nicola WannerFriedrich Koch-Nolte
Nov 19, 2021·Chemical Communications : Chem Comm·Jordi F KeijzerBauke Albada

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Methods Mentioned

BETA
protein modification
amidation
NMR
fluorescence imaging
xenografts

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