PMID: 18709968Aug 20, 2008Paper

Clustered secondary case rate in 10,088 patients with tuberculosis

Kekkaku : [Tuberculosis]
Takeo InoueSatoru Hattori

Abstract

To elucidate characteristics in clustered secondary TB patients transmitted from culture positive pulmonary TB patients. The subjects of this retrospective study were 10,088 TB patients registered in Aichi Prefecture between 1989 and 2003. Pulmonary TB was found in 8,629 patients, and 1,459 had extra-pulmonary TB. Bacteriological examination revealed sputum smear-positive (SPBP) in 3,332, sputum smear-negative bacillus-culture-positive (SNBP) in 2,139, and smear-negative bacillus-culture-negative (SNBN) in 3,158. All registration files were reviewed to identify epidemiological links of patients. When linked patients with an interval of the dates of registration of less than 10 years were found, the first case was considered as the index case, and the other patients were regarded as secondary cases. A clustered secondary case rate (CSR) for a category of patients was defined as follows; CSR=NCS/NA, where NA: number of TB patients in a category A, and NCS: number of secondary cases in category A. A cluster rate for a category of bacillary pulmonary patients was defined as follows; Cluster rate= (NIC+NCS)/ NA, where NA: number of TB patients in a category A, NIC: number of index cases in category A, and NCS: number of secondary ca...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.