Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment

The Journal of Immunology : Official Journal of the American Association of Immunologists
Gyong Hwa HongYou Sook Cho

Abstract

Recruitment and activation of dendritic cells (DCs) in the lungs are critical for Th2 responses in asthma, and CCL20 secreted from bronchial epithelial cells (BECs) is known to influence the recruitment of DCs. Because asthma is a disease that is closely associated with oxidative stress, we hypothesized that clusterin, an oxidative stress regulatory molecule, may have a role in the development of allergic airway inflammation. The aim of this study was to examine whether clusterin regulates CCL20 production from the BECs and the subsequent DC recruitment in the lungs. To verify the idea, clusterin knockout (Clu(-/-)), clusterin heterogeneous (Clu(+/-)), and wild-type mice were exposed intranasally to house dust mite (HDM) extract to induce allergic airway inflammation. We found that the total number of immune cells in bronchoalveolar lavage fluid and the lung was increased in Clu(-/-) and Clu(+/-) mice. Of these immune cells, inflammatory DCs (CD11b(+)CD11c(+)) and Ly6C(high) monocyte populations in the lung were significantly increased, which was accompanied by increased levels of various chemokines, including CCL20 in bronchoalveolar lavage fluid, and increased oxidative stress markers in the lung. Moreover, HDM-stimulated hum...Continue Reading

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Citations

Jan 11, 2018·Clinical and Experimental Otorhinolaryngology·Chang Hoon BaeYong-Dae Kim
Jul 26, 2018·Experimental Dermatology·Hyun Cheol BaeSang Wook Son
Nov 29, 2016·Pediatric Research·Jessica Balena-BornemanDavid Askenazi
Sep 8, 2018·PloS One·Yoshitaka KawaYoshihiro Nishimura
Aug 9, 2020·International Journal of Molecular Sciences·Drahomira HolmannovaZdenek Fiala
May 3, 2018·Experimental & Molecular Medicine·Gil-Soon ChoiHae-Sim Park
Nov 19, 2019·ELife·Sarah K HerringLiqin Zhao
Sep 4, 2019·Ageing Research Reviews·Praveen BathiniLavinia Alberi Auber
May 1, 2021·Cells·Jung Yeon HongMyung Hyun Sohn

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