Clustering and separation of hydrophobic nanoparticles in lipid bilayer explained by membrane mechanics

Scientific Reports
Matej DanielVeronika Kralj-Iglič

Abstract

Small hydrophobic gold nanoparticles with diameter lower than the membrane thickness can form clusters or uniformly distribute within the hydrophobic core of the bilayer. The coexistence of two stable phases (clustered and dispersed) indicates the energy barrier between nanoparticles. We calculated the distance dependence of the membrane-mediated interaction between two adjacent nanoparticles. In our model we consider two deformation modes: the monolayer bending and the hydroxycarbon chain stretching. Existence of an energy barrier between the clustered and the separated state of nanoparticles was predicted. Variation analysis of the membrane mechanical parameters revealed that the energy barrier between two membrane embedded nanoparticles is mainly the consequence of the bending deformation and not change of the thickness of the bilayer in the vicinity of nanoparticles. It is shown, that the forces between the nanoparticles embedded in the biological membrane could be either attractive or repulsive, depending on the mutual distance between them.

References

Jul 24, 1998·Biophysical Journal·S Tristram-NagleJ F Nagle
Nov 7, 1998·Biochimica Et Biophysica Acta·T GilM J Zuckermann
Oct 29, 2000·Biophysical Journal·C Nielsen, O S Andersen
Apr 20, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Markus Deserno
Jul 22, 2004·Bioconjugate Chemistry·Catherine M GoodmanVincent M Rotello
Sep 1, 2004·The European Physical Journal. E, Soft Matter·S MayM M Kozlov
Jul 6, 2005·European Biophysics Journal : EBJ·Veronika Kralj-IglicAles Iglic
Nov 29, 2005·Journal of Chemical Information and Modeling·Miha FosnaricSylvio May
Feb 21, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin Michael MüllerJemal Guven
Apr 11, 2006·The Journal of Membrane Biology·Norbert KucerkaJohn F Nagle
Jun 21, 2006·Molecular Membrane Biology·Henry HägerstrandAles Iglic
Jul 19, 2006·Angewandte Chemie·Gopakumar GopalakrishnanHorst Vogel
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Miha FosnaricSylvio May
May 22, 2009·Nature·Rob PhillipsPierre Sens
Feb 23, 2010·Advances in Colloid and Interface Science·Krassimir D Danov, Peter A Kralchevsky
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Anne-Florence BitbolJean-Baptiste Fournier
Nov 11, 2010·Physical Chemistry Chemical Physics : PCCP·Šárka PerutkováAleš Iglič
Apr 15, 2011·ACS Nano·Alexander S UrbanJochen Feldmann
Jul 28, 2013·International Journal of Molecular Sciences·Aljaž VelikonjaAleš Iglič
Dec 7, 2013·Chemistry and Physics of Lipids·Poornima Budime SanthoshNataša Poklar Ulrih
Mar 13, 2014·ACS Nano·Cécile BonnaudAlke Petri-Fink
Mar 22, 2014·Soft Matter·Joshua C BlackMichelle K Knowles
Apr 22, 2014·Chemistry and Physics of Lipids·John F NagleKiyotaka Akabori
Nov 12, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Roghayeh ImaniSamo Hudoklin
Dec 4, 2014·PloS One·Anil R Mhashal, Sudip Roy
May 27, 2015·Nature Communications·Mijo Simunovic, Gregory A Voth
Sep 30, 2015·Scientific Reports·Hirak K PatraAshutosh Tiwari
Oct 28, 2015·Soft Matter·Amir Houshang BahramiThomas R Weikl
Apr 10, 2016·Biochimica Et Biophysica Acta·Giulia Rossi, Luca Monticelli
Oct 16, 2016·Nanoscale·Panagiotis AngelikopoulosParaskevi Gkeka
Dec 14, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xin Yi, Huajian Gao

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Citations

Nov 14, 2019·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Uttam Kumar BasakPrabal K Maiti
Dec 4, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yan Zheng, Wanyi Tai
Nov 21, 2020·Physical Review. E·Konstantin V PiniginTimur R Galimzyanov
Dec 22, 2020·Structural Dynamics·Michihiro NagaoChristopher L Kitchens
Mar 23, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Anurag ChaudhuryJaydeep Kumar Basu
Dec 28, 2018·ACS Chemical Neuroscience·Joao L Carvalho-de-SouzaJames B Delehanty
Nov 24, 2020·ACS Nano·Parva PatelAlexander V Neimark

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