Clustering and switching in semantic fluency: predictors of the development of Alzheimer's disease

International Journal of Geriatric Psychiatry
Ana B FagundoManel Salamero

Abstract

The aims of the study are twofold: (1) to compare semantic fluency, clustering and switching performance among subjects with memory complaints, patients with Alzheimer Disease (AD), and healthy controls; and (2) to examine the clinical utility of the clustering/switching scoring system in the prediction of incident AD in subjects with memory complaints. A semantic fluency task was used to compare thirty eight subjects with memory complaints, forty two AD patients and twenty five healthy controls on the total number of words generated, clustering and switching performance. Subjects with memory complaints were followed-up for a maximum period of two years and re-evaluated. They remained in the memory complaints group (twenty eight subjects) or were defined as probable AD (ten subjects). AD patients generated fewer correct words (p < 0.001) and showed a reduction in clustering (p = 0.008) and switching (p < 0.001). Subjects with memory complaints showed a significant reduction in correct words (p < 0.001) and clustering performance (p = 0.008) compare to controls. In the first evaluation, the subgroup of patients who converted to AD at follow up produced less correct words (p < 0.01) and smaller clusters (p = 0.007) than the subgr...Continue Reading

References

Nov 7, 1999·Journal of Clinical and Experimental Neuropsychology·M O EpkerC Munro Cullum
Jun 16, 2000·Journal of Clinical and Experimental Neuropsychology·A K Troyer
Dec 23, 2000·Dementia and Geriatric Cognitive Disorders·N HironoM Sasaki
Nov 14, 2001·Neurobiology of Aging·B C DickersonL deToledo-Morrell
May 7, 2002·The Clinical Neuropsychologist·Jane H CerhanBradley F Boeve
Feb 1, 2003·BMJ : British Medical Journal·Katie PalmerLaura Fratiglioni
Apr 6, 2004·International Journal of Geriatric Psychiatry·J GuarchR Blesa
Jun 5, 2004·Neuropsychologia·Julie D HenryLouise H Phillips
Dec 2, 2004·Dementia and Geriatric Cognitive Disorders·Asmus VogelGunhild Waldemar
Feb 8, 2005·Schizophrenia Research·Vasilis P BozikasAthanasios Karavatos
May 17, 2005·Journal of the International Neuropsychological Society : JINS·Kirsten I TaylorPeter Brugger
Oct 3, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Rowena G Gomez, Desirée A White
Mar 22, 2007·Dementia and Geriatric Cognitive Disorders·Oskar HanssonKaj Blennow
Jul 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hiroshi Matsuda

❮ Previous
Next ❯

Citations

Apr 15, 2010·Journal of Clinical and Experimental Neuropsychology·Lauren LepowMichele K York
Apr 2, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Alyssa Weakley, Maureen Schmitter-Edgecombe
Jun 6, 2009·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Monica RosselliYaron Zoller
Jul 13, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Serguei V S Pakhomov, Laura S Hemmy
Feb 22, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·D G ClarkD C Marson
May 31, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kimberly Diggle MuellerMark A Sager
Jun 16, 2015·Frontiers in Psychology·Anne SauvagetJosé M Menchón
Apr 1, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Carlo ReverberiSimona Luzzi
Oct 30, 2015·Behavior Research Methods·Michael D LeeWilliam R Shankle
Jan 19, 2010·Journal of Psychopharmacology·Ana B FagundoRafael de la Torre
Jun 14, 2018·Biomarkers in Medicine·Annalena VenneriCamillo Marra
Nov 9, 2010·Journal of Clinical and Experimental Neuropsychology·Gitit KavéEugenia Agranov
Sep 17, 2020·Journal of Clinical and Experimental Neuropsychology·Jamie FordGeraint Price
Mar 11, 2017·Experimental Brain Research·Valeria OccelliK Sathian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.