PMID: 36148May 17, 1979

Clustering of fatty acids in phospholipid bilayers

Biochimica Et Biophysica Acta
H Hauser, W Guyer


From electrophoresis experiments it is concluded that acidic phospholipids incorporated in liquid crystalline phosphatidylcholine bilayers at neutral pH are randomly distributed. The same is true for spin-labelled fatty acids. In contrast, long chain fatty acids are not fully ionized at neutral pH and appear to be clustered, i.e. they segregate out into patches. Only at pH greater than 11 is the fatty acid-COOH group fully ionized and charge repulsion leads to a random distribution of the fatty acid within the plane of the bilayer.


Mar 13, 1975·Biochimica Et Biophysica Acta·D A CadenheadF Müller-Landau
Oct 6, 1975·Biochimica Et Biophysica Acta·J A Op den KampL L van Deenen
Jun 5, 1973·Biochemistry·E J Shimshick, H M McConnell
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·C J ScandellaH M McConnell
Mar 1, 1972·Chemistry and Physics of Lipids·M C PhillipsF Paltauf
Jul 1, 1967·Journal of Colloid and Interface Science·E D GoddardH C Kung

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