Clustering of genes coding for DNA binding proteins in a region of atypical evolution of the human genome

Journal of Molecular Evolution
Jose CastresanaM Mar Albà

Abstract

Comparison of the human and mouse genomes has revealed that significant variations in evolutionary rates exist among genomic regions and that a large part of this variation is interchromosomal. We confirm in this work, using a large collection of introns, that human chromosome 19 is the one that shows the highest divergence with respect to mouse. To search for other differences among chromosomes, we examine the distribution of gene functions in human and mouse chromosomes using the Gene Ontology definitions. We found by correspondence analysis that among the strongest clusterings of gene functions in human chromosomes is a group of genes coding for DNA binding proteins in chromosome 19. Interestingly, chromosome 19 also has a very high GC content, a feature that has been proposed to promote an opening of the chromatin, thereby facilitating binding of proteins to the DNA helix. In the mouse genome, however, a similar aggregation of genes coding for DNA binding proteins and high GC content cannot be found. This suggests that the distribution of genes coding for DNA binding proteins and the variations of the chromatin accessibility to these proteins are different in the human and mouse genomes. It is likely that the overall high s...Continue Reading

Citations

Sep 30, 2008·Eukaryotic Cell·Frédérique MoyrandGuilhem Janbon
Feb 22, 2013·BMC Evolutionary Biology·Macarena Toll-Riera, M Mar Albà
Dec 13, 2006·Genome Biology·Aurora Ruiz-HerreraTerence J Robinson
Oct 16, 2010·PLoS Computational Biology·Fátima Al-ShahrourJoaquín Dopazo
Jul 6, 2014·Gene·Timo TiirikkaMauno Vihinen
Dec 10, 2008·Molecular Biology and Evolution·Macarena Toll-RieraM Mar Albà
Oct 14, 2009·Molecular Biology and Evolution·Domènec Farré, M Mar Albà
Oct 7, 2015·BMC Evolutionary Biology·Juan A SubiranaXavier Messeguer
Feb 18, 2012·Molecular Biology and Evolution·Vladimir B SeplyarskiyGeorgii A Bazykin
Aug 26, 2020·Journal of Bacteriology·Juan A Subirana, Xavier Messeguer
Jun 3, 2021·International Journal of Molecular Sciences·Juan A Subirana, Xavier Messeguer

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