PMID: 9533399Apr 9, 1998Paper

Clustering of Pick bodies in patients with Pick's disease

Neuroscience Letters
R A ArmstrongP L Lantos

Abstract

Clustering of Pick bodies (PB) was studied in the frontal and temporal lobe in 10 cases of Pick's disease (PD). Pick bodies exhibited clustering in 47/50 (94%) brain areas analysed. In 20/50 (40%) brain areas, PB were present in a single large cluster > or =6400 microm in diameter, in 27/50 (54%) PB occurred in smaller clusters (200-3200 microm in diameter) which exhibited a regular periodicity relative to the tissue boundary, in 1/50 (2%) there was a regular distribution of individual PB and in 2/50 (4%), PB were randomly distributed. Mean cluster size of the PB was greater in the dentate gyrus compared with the inferior temporal gyrus and lateral occipitotemporal gyrus. Mean cluster size of PB in a brain region was positively correlated with the mean density of PB. Hence, PB exhibit essentially the same spatial patterns as senile plaques and neurofibrillary tangles in Alzheimer's disease (AD) and Lewy bodies in Dementia with Lewy bodies (DLB).

References

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Mar 7, 1997·Neuroscience Letters·R A ArmstrongP L Lantos

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Citations

Jun 8, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Richard A Armstrong, Nigel J Cairns
Mar 14, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Richard A Armstrong, Nigel J Cairns
Apr 25, 2012·Molecular Neurobiology·Thomas Arendt
Jul 10, 1999·Neuroscience Letters·R A ArmstrongP L Lantos
Jul 31, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·R A. ArmstrongN J. Cairns
Jan 1, 1999·Neuropathology : Official Journal of the Japanese Society of Neuropathology·R ArmstrongP Lantos
Jan 2, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·R A ArmstrongP L Lantos
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A ArmstrongPeter L Lantos
Jan 15, 2004·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A Armstrong
Jul 25, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A ArmstrongPeter L Lantos
May 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R A Armstrong, N J Cairns
Sep 13, 2012·International Journal of Alzheimer's Disease·Kristen E Funk, Jeff Kuret
May 27, 2009·International Journal of Molecular Sciences·Thomas ArendtMarkus Morawski
Oct 23, 2016·Journal of Neural Transmission·Richard A ArmstrongNigel J Cairns
Apr 12, 2017·Journal of Neurochemistry·Thomas ArendtUwe Ueberham

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