Clusters, Gaps, and Randomness: Vasovagal Syncope Recurrence Patterns

JACC. Clinical Electrophysiology
Inderjeet S SahotaRobert S Sheldon

Abstract

This study elucidated the temporal recurrence patterns of syncope in patients with frequent vasovagal syncope (VVS). Understanding the temporal distribution of fainting spells in syncope patients may illuminate biological processes and inform decision making. Patients from the POST 2 (Prevention of Syncope Trial 2) were included; all had VVS and fainted ≥4 times in the study year, providing ≥3 interevent intervals (IEIs). Only fainting spells separated by ≥1 day were included. IEI distributions were analyzed using Poisson modeling and cumulative sum distributions. Twenty-four patients (5 males, 19 females; mean 33 years of age) had a total of 286 syncopal events and 262 IEIs, with a median 6 IEI. They resembled excluded subjects in age and sex but fainted more often in their lives (median: 57 vs. 13 fainting spells, respectively; p < 0.0001) and in the previous year (median: 23 vs. 3 fainting spells, respectively; p < 0.0001). Subjects had a median IEI duration of 8 (interquartile range: 4 to 19) days. The IEI distributions were fit well by Poisson models with a median r2 of 0.94 (95% confidence interval: 0.91 to 0.97). The patients' Poisson rate constant frequencies were 7 to 263 fainting spells/year with a median rate of 19 f...Continue Reading

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Citations

Sep 11, 2021·Aerospace Medicine and Human Performance·Ryan A AndertonSean S ONunain

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