Clusters in Short-term Disease Course in Participants With Primary Dupuytren Disease

The Journal of Hand Surgery
Rosanne LantingPaul M N Werker

Abstract

The course of Dupuytren disease (DD) is thought to be progressive; however, the course differs for each patient. The purpose of this study was to study the rate and pattern of progression of DD. We prospectively analyzed the course of DD at intervals of 3 to 6 months in 247 Dutch participants with primary DD by measuring the surface area of nodules and cords and the total passive extension deficit. The association between surface area and Tubiana stage was tested with generalized estimating equations. Latent class models were used to study different clusters in changes regarding the course of the disease. The variance in disease course between participants was large. Regarding the change in surface area (in all fingers) and total passive extension deficit (in the ring and little finger), different clusters were observed. Progression of disease was seen but there were also signs of stability and even regression. Patients with a smaller surface area at baseline were more likely to exhibit regression. This study showed that DD is not always progressive and that up to 75% of patients have a different short-term disease course, such as stability or even regression of disease. This should be taken into account when evaluating the eff...Continue Reading

References

Sep 27, 2005·The Journal of Hand Surgery·Rachel M ReillyCharles A Goldfarb
Apr 3, 2012·The Journal of Hand Surgery·Gary M PessRachel A Pess
Jul 31, 2013·Plastic and Reconstructive Surgery·Rosanne LantingPaul M N Werker
Nov 23, 2013·Plastic and Reconstructive Surgery·Rosanne LantingEdwin R van den Heuvel

❮ Previous
Next ❯

Citations

Aug 17, 2016·BMC Musculoskeletal Disorders·Catherine BallJagdeep Nanchahal
Oct 25, 2017·Plastic and Reconstructive Surgery. Global Open·Chao ZhouRuud W Selles
May 12, 2017·The Journal of Hand Surgery, European Volume·M KadhumA Fleming
May 19, 2019·BMC Musculoskeletal Disorders·Sanne MolenkampDieuwke C Broekstra
Apr 2, 2021·The Bone & Joint Journal·Bente A van den BergeDieuwke C Broekstra
Oct 8, 2021·The Journal of Hand Surgery, European Volume·Sanne MolenkampPaul M N Werker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Hand Surgery
A von CampeC Meuli-Simmen
Annales de dermatologie et de vénéréologie
I MoulonguetN Baudot
Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
R TUBIANA, P VALENTIN
© 2022 Meta ULC. All rights reserved