Clusters of ancestrally related genes that show paralogy in whole or in part are a major feature of the genomes of humans and other species.

PloS One
Michael B WalkerKenneth Paigen

Abstract

Arrangements of genes along chromosomes are a product of evolutionary processes, and we can expect that preferable arrangements will prevail over the span of evolutionary time, often being reflected in the non-random clustering of structurally and/or functionally related genes. Such non-random arrangements can arise by two distinct evolutionary processes: duplications of DNA sequences that give rise to clusters of genes sharing both sequence similarity and common sequence features and the migration together of genes related by function, but not by common descent. To provide a background for distinguishing between the two, which is important for future efforts to unravel the evolutionary processes involved, we here provide a description of the extent to which ancestrally related genes are found in proximity.Towards this purpose, we combined information from five genomic datasets, InterPro, SCOP, PANTHER, Ensembl protein families, and Ensembl gene paralogs. The results are provided in publicly available datasets (http://cgd.jax.org/datasets/clustering/paraclustering.shtml) describing the extent to which ancestrally related genes are in proximity beyond what is expected by chance (i.e. form paraclusters) in the human and nine othe...Continue Reading

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Citations

Jul 18, 2012·Cell Research·Kenneth Paigen, Petko Petkov

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Software Mentioned

Biomart
BLASTP
TreeBeST
Ensembl
PANTHER HMM
PANTHER
InParanoid

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